Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor

BACKGROUND: Alisertib (MLN8237) is an investigational, oral, selective Aurora A kinase inhibitor. Aurora A contains two functional single nucleotide polymorphisms (SNPs; codon 31 [F/I] and codon 57 [V/I]) that lead to functional changes. This study investigated the prognostic and predictive signific...

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Detalles Bibliográficos
Autores principales: Niu, Huifeng, Shin, Hyunjin, Gao, Feng, Zhang, Jacob, Bahamon, Brittany, Danaee, Hadi, Melichar, Bohuslav, Schilder, Russell J., Coleman, Robert L., Falchook, Gerald, Adenis, Antoine, Behbakht, Kian, DeMichele, Angela, Dees, Elizabeth Claire, Perez, Kimberly, Matulonis, Ursula, Sawrycki, Piotr, Huebner, Dirk, Ecsedy, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704062/
https://www.ncbi.nlm.nih.gov/pubmed/29122619
http://dx.doi.org/10.1016/j.ebiom.2017.10.015

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