Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

Telomerase-specific replication-competent adenoviruses (Ads), i.e., TRADs, which possess an E1 gene expression cassette driven by the human telomerase reverse transcriptase promoter, are promising agents for cancer treatment. However, even though oncolytic Ads, including TRAD, are intratumorally adm...

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Detalles Bibliográficos
Autores principales: Machitani, Mitsuhiro, Sakurai, Fuminori, Wakabayashi, Keisaku, Nakatani, Kosuke, Tachibana, Masashi, Kato, Nobuyuki, Fujiwara, Toshiyoshi, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704103/
https://www.ncbi.nlm.nih.gov/pubmed/29202008
http://dx.doi.org/10.1016/j.omto.2017.10.003

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