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Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of l...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704120/ https://www.ncbi.nlm.nih.gov/pubmed/29104254 http://dx.doi.org/10.3390/jcm6110103 |
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author | Sherwin, LeeAnne B. Ozoji, Onyinyechi M. Boulineaux, Christina M. Joseph, Paule V. Fourie, Nicolaas H. Abey, Sarah K. Zhang, Xuemin Henderson, Wendy A. |
author_facet | Sherwin, LeeAnne B. Ozoji, Onyinyechi M. Boulineaux, Christina M. Joseph, Paule V. Fourie, Nicolaas H. Abey, Sarah K. Zhang, Xuemin Henderson, Wendy A. |
author_sort | Sherwin, LeeAnne B. |
collection | PubMed |
description | Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of life (QOL). Identifying factors associated with dysfunction have the potential to enhance outcomes. Participants with IBS (n = 41) and healthy volunteers (n = 74) were recruited into this cross-sectional, descriptive, natural history protocol at the National Institute of Health, Clinical Center. Demographic characteristics were self-reported. QOL was assessed with the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire. Statistical analysis included descriptive statistics, factorial ANOVA, and multiple regression. Individuals with IBS reported lower QOL scores across all QOL-subscales compared to healthy controls. Normal-weight women and overweight men with IBS reported the greatest QOL impairment. Body fat percent had confounding effects on the relationship between IBS and QOL. The disparity between QOL scores in participants with IBS by both gender and weight groups may reflect different social pressures perceived by normal and overweight women and men. These findings enhance the recognition of the disparities in patients with chronic symptoms and thereby lead to personalized assessment and interventions to improve their QOL. |
format | Online Article Text |
id | pubmed-5704120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57041202017-11-30 Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome Sherwin, LeeAnne B. Ozoji, Onyinyechi M. Boulineaux, Christina M. Joseph, Paule V. Fourie, Nicolaas H. Abey, Sarah K. Zhang, Xuemin Henderson, Wendy A. J Clin Med Article Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of life (QOL). Identifying factors associated with dysfunction have the potential to enhance outcomes. Participants with IBS (n = 41) and healthy volunteers (n = 74) were recruited into this cross-sectional, descriptive, natural history protocol at the National Institute of Health, Clinical Center. Demographic characteristics were self-reported. QOL was assessed with the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire. Statistical analysis included descriptive statistics, factorial ANOVA, and multiple regression. Individuals with IBS reported lower QOL scores across all QOL-subscales compared to healthy controls. Normal-weight women and overweight men with IBS reported the greatest QOL impairment. Body fat percent had confounding effects on the relationship between IBS and QOL. The disparity between QOL scores in participants with IBS by both gender and weight groups may reflect different social pressures perceived by normal and overweight women and men. These findings enhance the recognition of the disparities in patients with chronic symptoms and thereby lead to personalized assessment and interventions to improve their QOL. MDPI 2017-11-01 /pmc/articles/PMC5704120/ /pubmed/29104254 http://dx.doi.org/10.3390/jcm6110103 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sherwin, LeeAnne B. Ozoji, Onyinyechi M. Boulineaux, Christina M. Joseph, Paule V. Fourie, Nicolaas H. Abey, Sarah K. Zhang, Xuemin Henderson, Wendy A. Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title | Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_full | Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_fullStr | Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_full_unstemmed | Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_short | Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_sort | gender and weight influence quality of life in irritable bowel syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704120/ https://www.ncbi.nlm.nih.gov/pubmed/29104254 http://dx.doi.org/10.3390/jcm6110103 |
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