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Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders

Epigenetic effects of medications are an evolving field of medicine, and can change the landscape of drug development. The aim of this paper is to systematically review the literature of the relationship between common medications used for treatment of bipolar disorders and epigenetic modifications....

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Autores principales: Lockwood, Laura E., Youssef, Nagy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704161/
https://www.ncbi.nlm.nih.gov/pubmed/29156546
http://dx.doi.org/10.3390/brainsci7110154
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author Lockwood, Laura E.
Youssef, Nagy A.
author_facet Lockwood, Laura E.
Youssef, Nagy A.
author_sort Lockwood, Laura E.
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description Epigenetic effects of medications are an evolving field of medicine, and can change the landscape of drug development. The aim of this paper is to systematically review the literature of the relationship between common medications used for treatment of bipolar disorders and epigenetic modifications. MedLine/PubMed searches were performed based on pre-specified inclusion criteria from inception to November 2017. Six animal and human studies met the inclusion criteria. These studies examined the epigenetic changes in the main classes of medications that are used in bipolar disorders, namely mood stabilizers and antipsychotics. Although these initial studies have small to moderate sample size, they generally suggest an evolving and accumulating evidence of epigenetic changes that are associated with several of the medications that are used in bipolar I and II disorders. In this manuscript, we describe the specific epigenetic changes that are associated with the medications studied. Of the studies reviewed, five of the six studies revealed epigenetic changes associated with the use of mood stabilizers or antipsychotic medications. This review contributes to future research directions. Further understanding of the complexities of the epigenome and the untangling of the effects and contributions of disease states versus medications is crucial for the future of drug design and the development of new therapeutics. Epigenetic therapeutics hold great promise for complex disease treatment and personalized interventions, including psychiatric diseases.
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spelling pubmed-57041612017-11-30 Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders Lockwood, Laura E. Youssef, Nagy A. Brain Sci Review Epigenetic effects of medications are an evolving field of medicine, and can change the landscape of drug development. The aim of this paper is to systematically review the literature of the relationship between common medications used for treatment of bipolar disorders and epigenetic modifications. MedLine/PubMed searches were performed based on pre-specified inclusion criteria from inception to November 2017. Six animal and human studies met the inclusion criteria. These studies examined the epigenetic changes in the main classes of medications that are used in bipolar disorders, namely mood stabilizers and antipsychotics. Although these initial studies have small to moderate sample size, they generally suggest an evolving and accumulating evidence of epigenetic changes that are associated with several of the medications that are used in bipolar I and II disorders. In this manuscript, we describe the specific epigenetic changes that are associated with the medications studied. Of the studies reviewed, five of the six studies revealed epigenetic changes associated with the use of mood stabilizers or antipsychotic medications. This review contributes to future research directions. Further understanding of the complexities of the epigenome and the untangling of the effects and contributions of disease states versus medications is crucial for the future of drug design and the development of new therapeutics. Epigenetic therapeutics hold great promise for complex disease treatment and personalized interventions, including psychiatric diseases. MDPI 2017-11-18 /pmc/articles/PMC5704161/ /pubmed/29156546 http://dx.doi.org/10.3390/brainsci7110154 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lockwood, Laura E.
Youssef, Nagy A.
Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders
title Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders
title_full Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders
title_fullStr Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders
title_full_unstemmed Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders
title_short Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders
title_sort systematic review of epigenetic effects of pharmacological agents for bipolar disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704161/
https://www.ncbi.nlm.nih.gov/pubmed/29156546
http://dx.doi.org/10.3390/brainsci7110154
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