Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation

Numerous mutations have been observed in the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase (RTK) in both germline and sporadic neuroblastoma. Here, we have investigated the Y1278S mutation, observed in four patient cases, and its potential importance in the activation of the full length...

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Detalles Bibliográficos
Autores principales: Guan, Jikui, Yamazaki, Yasuo, Chand, Damini, van Dijk, Jesper R., Ruuth, Kristina, Palmer, Ruth H., Hallberg, Bengt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704167/
https://www.ncbi.nlm.nih.gov/pubmed/29084134
http://dx.doi.org/10.3390/cancers9110149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704167/
https://www.ncbi.nlm.nih.gov/pubmed/29084134
http://dx.doi.org/10.3390/cancers9110149

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