Genomic Destabilization Triggered by Replication Stress during Senescence

Most cancers develop after middle age, and are often associated with multiple mutations and genomic instability, implying that genomic destabilization is critical for age-related tumor development. In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which...

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Detalles Bibliográficos
Autores principales: Minakawa, Yusuke, Shimizu, Atsuhiro, Matsuno, Yusuke, Yoshioka, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704177/
http://dx.doi.org/10.3390/cancers9110159
Descripción
Sumario:Most cancers develop after middle age, and are often associated with multiple mutations and genomic instability, implying that genomic destabilization is critical for age-related tumor development. In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which is associated with a higher risk of genomic destabilization; and (2) the contributions of genomic destabilization to cancer development.

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