Genomic Destabilization Triggered by Replication Stress during Senescence

Most cancers develop after middle age, and are often associated with multiple mutations and genomic instability, implying that genomic destabilization is critical for age-related tumor development. In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which...

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Detalles Bibliográficos
Autores principales: Minakawa, Yusuke, Shimizu, Atsuhiro, Matsuno, Yusuke, Yoshioka, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704177/
http://dx.doi.org/10.3390/cancers9110159
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author Minakawa, Yusuke
Shimizu, Atsuhiro
Matsuno, Yusuke
Yoshioka, Ken-ichi
author_facet Minakawa, Yusuke
Shimizu, Atsuhiro
Matsuno, Yusuke
Yoshioka, Ken-ichi
author_sort Minakawa, Yusuke
collection PubMed
description Most cancers develop after middle age, and are often associated with multiple mutations and genomic instability, implying that genomic destabilization is critical for age-related tumor development. In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which is associated with a higher risk of genomic destabilization; and (2) the contributions of genomic destabilization to cancer development.
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spelling pubmed-57041772017-11-30 Genomic Destabilization Triggered by Replication Stress during Senescence Minakawa, Yusuke Shimizu, Atsuhiro Matsuno, Yusuke Yoshioka, Ken-ichi Cancers (Basel) Perspective Most cancers develop after middle age, and are often associated with multiple mutations and genomic instability, implying that genomic destabilization is critical for age-related tumor development. In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which is associated with a higher risk of genomic destabilization; and (2) the contributions of genomic destabilization to cancer development. MDPI 2017-11-21 /pmc/articles/PMC5704177/ http://dx.doi.org/10.3390/cancers9110159 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Minakawa, Yusuke
Shimizu, Atsuhiro
Matsuno, Yusuke
Yoshioka, Ken-ichi
Genomic Destabilization Triggered by Replication Stress during Senescence
title Genomic Destabilization Triggered by Replication Stress during Senescence
title_full Genomic Destabilization Triggered by Replication Stress during Senescence
title_fullStr Genomic Destabilization Triggered by Replication Stress during Senescence
title_full_unstemmed Genomic Destabilization Triggered by Replication Stress during Senescence
title_short Genomic Destabilization Triggered by Replication Stress during Senescence
title_sort genomic destabilization triggered by replication stress during senescence
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704177/
http://dx.doi.org/10.3390/cancers9110159
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AT shimizuatsuhiro genomicdestabilizationtriggeredbyreplicationstressduringsenescence
AT matsunoyusuke genomicdestabilizationtriggeredbyreplicationstressduringsenescence
AT yoshiokakenichi genomicdestabilizationtriggeredbyreplicationstressduringsenescence

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