Long-term exposure to ethanol downregulates tight junction proteins through the protein kinase Cα signaling pathway in human cerebral microvascular endothelial cells

Brain microvascular endothelial cells (BMECs) are the primary component of the blood-brain barrier (BBB). Tight junction (TJ) proteins, including claudin, occludin and zonula occludens (ZO)-1, ZO-2 and ZO-3, maintain the structural integrity of BMECs. Ethanol activates the assembly and disassembly o...

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Detalles Bibliográficos
Autores principales: Yu, Hao, Wang, Changliang, Wang, Xiaolong, Wang, Hongbo, Zhang, Chunan, You, Jiabin, Wang, Pengfei, Feng, Chunmei, Xu, Guohui, Zhao, Rui, Wu, Xu, Zhang, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704308/
https://www.ncbi.nlm.nih.gov/pubmed/29201181
http://dx.doi.org/10.3892/etm.2017.5180

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