Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory

The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet’s Clonal Selection Theory, the evidence is briefly reviewed and updated.

Detalles Bibliográficos
Autor principal: Steele, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704389/
https://www.ncbi.nlm.nih.gov/pubmed/29218047
http://dx.doi.org/10.3389/fimmu.2017.01611
Descripción
Sumario:The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet’s Clonal Selection Theory, the evidence is briefly reviewed and updated.

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