Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient

Drug-induced liver injury (DILI) represents liver damage from various therapeutic drugs. Antimicrobials are among the most common causes of DILI. We report a case of hepatic toxicity due to Trimethoprim-sulfamethoxazole (TMP-SMX) in a patient who underwent renal transplantation. Diagnosis has been m...

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Autores principales: Slim, R., Asmar, N., Yaghi, C., Honein, K., Sayegh, R., Chelala, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704419/
https://www.ncbi.nlm.nih.gov/pubmed/29217891
http://dx.doi.org/10.4103/ijn.IJN_339_16
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author Slim, R.
Asmar, N.
Yaghi, C.
Honein, K.
Sayegh, R.
Chelala, D.
author_facet Slim, R.
Asmar, N.
Yaghi, C.
Honein, K.
Sayegh, R.
Chelala, D.
author_sort Slim, R.
collection PubMed
description Drug-induced liver injury (DILI) represents liver damage from various therapeutic drugs. Antimicrobials are among the most common causes of DILI. We report a case of hepatic toxicity due to Trimethoprim-sulfamethoxazole (TMP-SMX) in a patient who underwent renal transplantation. Diagnosis has been made after a careful history taking, exclusion of competing etiologies and reversal of biochemical abnormalities after withdrawal of the antibiotic. TMP-SMX liver toxicity is well known but remains unpredictable and is rarely reported.
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spelling pubmed-57044192017-12-07 Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient Slim, R. Asmar, N. Yaghi, C. Honein, K. Sayegh, R. Chelala, D. Indian J Nephrol Case Report Drug-induced liver injury (DILI) represents liver damage from various therapeutic drugs. Antimicrobials are among the most common causes of DILI. We report a case of hepatic toxicity due to Trimethoprim-sulfamethoxazole (TMP-SMX) in a patient who underwent renal transplantation. Diagnosis has been made after a careful history taking, exclusion of competing etiologies and reversal of biochemical abnormalities after withdrawal of the antibiotic. TMP-SMX liver toxicity is well known but remains unpredictable and is rarely reported. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5704419/ /pubmed/29217891 http://dx.doi.org/10.4103/ijn.IJN_339_16 Text en Copyright: © 2017 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Slim, R.
Asmar, N.
Yaghi, C.
Honein, K.
Sayegh, R.
Chelala, D.
Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient
title Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient
title_full Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient
title_fullStr Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient
title_full_unstemmed Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient
title_short Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient
title_sort trimethoprim-sulfamethoxazole-induced hepatotoxicity in a renal transplant patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704419/
https://www.ncbi.nlm.nih.gov/pubmed/29217891
http://dx.doi.org/10.4103/ijn.IJN_339_16
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