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IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice

Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC home...

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Autores principales: Wang, Yangping, Bai, Yang, Li, Yashu, Liang, Guangping, Jiang, Yufeng, Liu, Zhongyang, Liu, Meixi, Hao, Jianlei, Zhang, Xiaorong, Hu, Xiaohong, Chen, Jian, Wang, Rupeng, Yin, Zhinan, Wu, Jun, Luo, Gaoxing, He, Weifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705622/
https://www.ncbi.nlm.nih.gov/pubmed/29225596
http://dx.doi.org/10.3389/fimmu.2017.01557
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author Wang, Yangping
Bai, Yang
Li, Yashu
Liang, Guangping
Jiang, Yufeng
Liu, Zhongyang
Liu, Meixi
Hao, Jianlei
Zhang, Xiaorong
Hu, Xiaohong
Chen, Jian
Wang, Rupeng
Yin, Zhinan
Wu, Jun
Luo, Gaoxing
He, Weifeng
author_facet Wang, Yangping
Bai, Yang
Li, Yashu
Liang, Guangping
Jiang, Yufeng
Liu, Zhongyang
Liu, Meixi
Hao, Jianlei
Zhang, Xiaorong
Hu, Xiaohong
Chen, Jian
Wang, Rupeng
Yin, Zhinan
Wu, Jun
Luo, Gaoxing
He, Weifeng
author_sort Wang, Yangping
collection PubMed
description Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC homeostasis in streptozotocin -induced diabetic animals. However, the role of IL-15 in impaired diabetic wound healing remains unknown. Here, we found that, through rescuing the insufficient activation of DETCs, IL-15 increased IGF-1 production by DETCs and thereby promoted diabetic skin wound repair. Regulation of IGF-1 in DETCs by IL-15 was partly dependent on the mTOR pathway. In addition, expression of IL-15 and IGF-1 were positively correlated in wounded epidermis. Together, our data indicated that IL-15 enhanced IGF-1 production by DETCs to promoting diabetic wound repair, suggesting IL-15 as a potential therapeutic agent for managing diabetic wound healing.
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spelling pubmed-57056222017-12-08 IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice Wang, Yangping Bai, Yang Li, Yashu Liang, Guangping Jiang, Yufeng Liu, Zhongyang Liu, Meixi Hao, Jianlei Zhang, Xiaorong Hu, Xiaohong Chen, Jian Wang, Rupeng Yin, Zhinan Wu, Jun Luo, Gaoxing He, Weifeng Front Immunol Immunology Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC homeostasis in streptozotocin -induced diabetic animals. However, the role of IL-15 in impaired diabetic wound healing remains unknown. Here, we found that, through rescuing the insufficient activation of DETCs, IL-15 increased IGF-1 production by DETCs and thereby promoted diabetic skin wound repair. Regulation of IGF-1 in DETCs by IL-15 was partly dependent on the mTOR pathway. In addition, expression of IL-15 and IGF-1 were positively correlated in wounded epidermis. Together, our data indicated that IL-15 enhanced IGF-1 production by DETCs to promoting diabetic wound repair, suggesting IL-15 as a potential therapeutic agent for managing diabetic wound healing. Frontiers Media S.A. 2017-11-24 /pmc/articles/PMC5705622/ /pubmed/29225596 http://dx.doi.org/10.3389/fimmu.2017.01557 Text en Copyright © 2017 Wang, Bai, Li, Liang, Jiang, Liu, Liu, Hao, Zhang, Hu, Chen, Wang, Yin, Wu, Luo and He. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Yangping
Bai, Yang
Li, Yashu
Liang, Guangping
Jiang, Yufeng
Liu, Zhongyang
Liu, Meixi
Hao, Jianlei
Zhang, Xiaorong
Hu, Xiaohong
Chen, Jian
Wang, Rupeng
Yin, Zhinan
Wu, Jun
Luo, Gaoxing
He, Weifeng
IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice
title IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice
title_full IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice
title_fullStr IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice
title_full_unstemmed IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice
title_short IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice
title_sort il-15 enhances activation and igf-1 production of dendritic epidermal t cells to promote wound healing in diabetic mice
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705622/
https://www.ncbi.nlm.nih.gov/pubmed/29225596
http://dx.doi.org/10.3389/fimmu.2017.01557
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