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IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice
Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC home...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705622/ https://www.ncbi.nlm.nih.gov/pubmed/29225596 http://dx.doi.org/10.3389/fimmu.2017.01557 |
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author | Wang, Yangping Bai, Yang Li, Yashu Liang, Guangping Jiang, Yufeng Liu, Zhongyang Liu, Meixi Hao, Jianlei Zhang, Xiaorong Hu, Xiaohong Chen, Jian Wang, Rupeng Yin, Zhinan Wu, Jun Luo, Gaoxing He, Weifeng |
author_facet | Wang, Yangping Bai, Yang Li, Yashu Liang, Guangping Jiang, Yufeng Liu, Zhongyang Liu, Meixi Hao, Jianlei Zhang, Xiaorong Hu, Xiaohong Chen, Jian Wang, Rupeng Yin, Zhinan Wu, Jun Luo, Gaoxing He, Weifeng |
author_sort | Wang, Yangping |
collection | PubMed |
description | Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC homeostasis in streptozotocin -induced diabetic animals. However, the role of IL-15 in impaired diabetic wound healing remains unknown. Here, we found that, through rescuing the insufficient activation of DETCs, IL-15 increased IGF-1 production by DETCs and thereby promoted diabetic skin wound repair. Regulation of IGF-1 in DETCs by IL-15 was partly dependent on the mTOR pathway. In addition, expression of IL-15 and IGF-1 were positively correlated in wounded epidermis. Together, our data indicated that IL-15 enhanced IGF-1 production by DETCs to promoting diabetic wound repair, suggesting IL-15 as a potential therapeutic agent for managing diabetic wound healing. |
format | Online Article Text |
id | pubmed-5705622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57056222017-12-08 IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice Wang, Yangping Bai, Yang Li, Yashu Liang, Guangping Jiang, Yufeng Liu, Zhongyang Liu, Meixi Hao, Jianlei Zhang, Xiaorong Hu, Xiaohong Chen, Jian Wang, Rupeng Yin, Zhinan Wu, Jun Luo, Gaoxing He, Weifeng Front Immunol Immunology Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC homeostasis in streptozotocin -induced diabetic animals. However, the role of IL-15 in impaired diabetic wound healing remains unknown. Here, we found that, through rescuing the insufficient activation of DETCs, IL-15 increased IGF-1 production by DETCs and thereby promoted diabetic skin wound repair. Regulation of IGF-1 in DETCs by IL-15 was partly dependent on the mTOR pathway. In addition, expression of IL-15 and IGF-1 were positively correlated in wounded epidermis. Together, our data indicated that IL-15 enhanced IGF-1 production by DETCs to promoting diabetic wound repair, suggesting IL-15 as a potential therapeutic agent for managing diabetic wound healing. Frontiers Media S.A. 2017-11-24 /pmc/articles/PMC5705622/ /pubmed/29225596 http://dx.doi.org/10.3389/fimmu.2017.01557 Text en Copyright © 2017 Wang, Bai, Li, Liang, Jiang, Liu, Liu, Hao, Zhang, Hu, Chen, Wang, Yin, Wu, Luo and He. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wang, Yangping Bai, Yang Li, Yashu Liang, Guangping Jiang, Yufeng Liu, Zhongyang Liu, Meixi Hao, Jianlei Zhang, Xiaorong Hu, Xiaohong Chen, Jian Wang, Rupeng Yin, Zhinan Wu, Jun Luo, Gaoxing He, Weifeng IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice |
title | IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice |
title_full | IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice |
title_fullStr | IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice |
title_full_unstemmed | IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice |
title_short | IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice |
title_sort | il-15 enhances activation and igf-1 production of dendritic epidermal t cells to promote wound healing in diabetic mice |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705622/ https://www.ncbi.nlm.nih.gov/pubmed/29225596 http://dx.doi.org/10.3389/fimmu.2017.01557 |
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