A half-site multimeric enzyme achieves its cooperativity without conformational changes

Cooperativity is a feature many multimeric proteins use to control activity. Here we show that the bacterial heptose isomerase GmhA displays homotropic positive and negative cooperativity among its four protomers. Most similar proteins achieve this through conformational changes: GmhA instead employ...

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Detalles Bibliográficos
Autores principales: Vivoli, Mirella, Pang, Jiayun, Harmer, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705639/
https://www.ncbi.nlm.nih.gov/pubmed/29184087
http://dx.doi.org/10.1038/s41598-017-16421-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705639/
https://www.ncbi.nlm.nih.gov/pubmed/29184087
http://dx.doi.org/10.1038/s41598-017-16421-2

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