Cargando…
Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants
Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with u...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705725/ https://www.ncbi.nlm.nih.gov/pubmed/29184093 http://dx.doi.org/10.1038/s41598-017-16606-9 |
_version_ | 1783282081123532800 |
---|---|
author | Stearns, Jennifer C. Simioni, Julia Gunn, Elizabeth McDonald, Helen Holloway, Alison C. Thabane, Lehana Mousseau, Andrea Schertzer, Jonathan D. Ratcliffe, Elyanne M. Rossi, Laura Surette, Michael G. Morrison, Katherine M. Hutton, Eileen K. |
author_facet | Stearns, Jennifer C. Simioni, Julia Gunn, Elizabeth McDonald, Helen Holloway, Alison C. Thabane, Lehana Mousseau, Andrea Schertzer, Jonathan D. Ratcliffe, Elyanne M. Rossi, Laura Surette, Michael G. Morrison, Katherine M. Hutton, Eileen K. |
author_sort | Stearns, Jennifer C. |
collection | PubMed |
description | Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with uncomplicated pregnancies. Here we compare bacterial community succession in infants born vaginally, with no exposure to antibiotics (n = 53), with infants who were exposed to intrapartum antibiotic prophylaxis (IAP) for Group B Streptococcus (GBS; n = 14), and infants born by C-section (n = 7). Molecular profiles of the 16 S rRNA genes indicate that there is a delay in the expansion of Bifidobacterium, which was the dominate infant gut colonizer, over the first 12 weeks and a persistence of Escherichia when IAP for GBS exposure is present during vaginal labour. Longer duration of IAP exposure increased the magnitude of the effect on Bifidobacterium populations, suggesting a longer delay in microbial community maturation. As with prior studies, we found altered gut colonisation following C-section that included a notable lack of Bacteroidetes. This study found that exposure of infants to IAP for GBS during vaginal birth affected aspects of gut microbial ecology that, although dramatic at early time points, disappeared by 12 weeks of age in most infants. |
format | Online Article Text |
id | pubmed-5705725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57057252017-12-05 Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants Stearns, Jennifer C. Simioni, Julia Gunn, Elizabeth McDonald, Helen Holloway, Alison C. Thabane, Lehana Mousseau, Andrea Schertzer, Jonathan D. Ratcliffe, Elyanne M. Rossi, Laura Surette, Michael G. Morrison, Katherine M. Hutton, Eileen K. Sci Rep Article Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with uncomplicated pregnancies. Here we compare bacterial community succession in infants born vaginally, with no exposure to antibiotics (n = 53), with infants who were exposed to intrapartum antibiotic prophylaxis (IAP) for Group B Streptococcus (GBS; n = 14), and infants born by C-section (n = 7). Molecular profiles of the 16 S rRNA genes indicate that there is a delay in the expansion of Bifidobacterium, which was the dominate infant gut colonizer, over the first 12 weeks and a persistence of Escherichia when IAP for GBS exposure is present during vaginal labour. Longer duration of IAP exposure increased the magnitude of the effect on Bifidobacterium populations, suggesting a longer delay in microbial community maturation. As with prior studies, we found altered gut colonisation following C-section that included a notable lack of Bacteroidetes. This study found that exposure of infants to IAP for GBS during vaginal birth affected aspects of gut microbial ecology that, although dramatic at early time points, disappeared by 12 weeks of age in most infants. Nature Publishing Group UK 2017-11-28 /pmc/articles/PMC5705725/ /pubmed/29184093 http://dx.doi.org/10.1038/s41598-017-16606-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Stearns, Jennifer C. Simioni, Julia Gunn, Elizabeth McDonald, Helen Holloway, Alison C. Thabane, Lehana Mousseau, Andrea Schertzer, Jonathan D. Ratcliffe, Elyanne M. Rossi, Laura Surette, Michael G. Morrison, Katherine M. Hutton, Eileen K. Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants |
title | Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants |
title_full | Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants |
title_fullStr | Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants |
title_full_unstemmed | Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants |
title_short | Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants |
title_sort | intrapartum antibiotics for gbs prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705725/ https://www.ncbi.nlm.nih.gov/pubmed/29184093 http://dx.doi.org/10.1038/s41598-017-16606-9 |
work_keys_str_mv | AT stearnsjenniferc intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT simionijulia intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT gunnelizabeth intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT mcdonaldhelen intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT hollowayalisonc intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT thabanelehana intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT mousseauandrea intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT schertzerjonathand intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT ratcliffeelyannem intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT rossilaura intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT surettemichaelg intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT morrisonkatherinem intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants AT huttoneileenk intrapartumantibioticsforgbsprophylaxisaltercolonizationpatternsintheearlyinfantgutmicrobiomeoflowriskinfants |