Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes

Certain “protective” major histocompatibility complex class I (MHC-I) alleles, such as B*57 and B*27, are associated with long-term control of HIV-1 in vivo mediated by the CD8(+) cytotoxic-T-lymphocyte (CTL) response. However, the mechanism of such superior protection is not fully understood. Here...

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Detalles Bibliográficos
Autores principales: Du, Yushen, Zhang, Tian-Hao, Dai, Lei, Zheng, Xiaojuan, Gorin, Aleksandr M., Oishi, John, Wu, Ting-Ting, Yoshizawa, Janice M., Li, Xinmin, Yang, Otto O., Martinez-Maza, Otoniel, Detels, Roger, Sun, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705913/
https://www.ncbi.nlm.nih.gov/pubmed/29184023
http://dx.doi.org/10.1128/mBio.01050-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705913/
https://www.ncbi.nlm.nih.gov/pubmed/29184023
http://dx.doi.org/10.1128/mBio.01050-17

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