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Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria

Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance. In their recent article, Martin Vestergaard et al. (mBio 8:e01114-17, 2017, https://doi.org/1...

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Detalles Bibliográficos
Autores principales: Baquero, Fernando, Martínez, José-Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705924/
https://www.ncbi.nlm.nih.gov/pubmed/29184022
http://dx.doi.org/10.1128/mBio.01950-17
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author Baquero, Fernando
Martínez, José-Luis
author_facet Baquero, Fernando
Martínez, José-Luis
author_sort Baquero, Fernando
collection PubMed
description Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance. In their recent article, Martin Vestergaard et al. (mBio 8:e01114-17, 2017, https://doi.org/10.1128/mBio.01114-17) illustrate the possibility of converting intrinsically resistant bacteria into susceptible ones. They reported that inhibition of a central metabolic enzyme, ATP synthase, allows otherwise ineffective polymyxin antibiotics to act on Staphylococcus aureus. The study of the intrinsic resistome of bacterial pathogens has shown that several metabolic genes, including multigene transcriptional regulators, contribute to antibiotic resistance. In some cases, these genes only marginally increase antibiotic resistance, but reduced levels of susceptibility might be critical in the evolution or resistance under low antibiotic concentrations or in the clinical response of highly resistant bacteria. Drug interventions on bacterial metabolism might constitute a critical adjuvant therapy in combination with antibiotics to ensure susceptibility of pathogens with intrinsic or acquired antimicrobial resistance.
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spelling pubmed-57059242017-12-01 Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria Baquero, Fernando Martínez, José-Luis mBio Commentary Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance. In their recent article, Martin Vestergaard et al. (mBio 8:e01114-17, 2017, https://doi.org/10.1128/mBio.01114-17) illustrate the possibility of converting intrinsically resistant bacteria into susceptible ones. They reported that inhibition of a central metabolic enzyme, ATP synthase, allows otherwise ineffective polymyxin antibiotics to act on Staphylococcus aureus. The study of the intrinsic resistome of bacterial pathogens has shown that several metabolic genes, including multigene transcriptional regulators, contribute to antibiotic resistance. In some cases, these genes only marginally increase antibiotic resistance, but reduced levels of susceptibility might be critical in the evolution or resistance under low antibiotic concentrations or in the clinical response of highly resistant bacteria. Drug interventions on bacterial metabolism might constitute a critical adjuvant therapy in combination with antibiotics to ensure susceptibility of pathogens with intrinsic or acquired antimicrobial resistance. American Society for Microbiology 2017-11-28 /pmc/articles/PMC5705924/ /pubmed/29184022 http://dx.doi.org/10.1128/mBio.01950-17 Text en Copyright © 2017 Baquero and Martínez. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Baquero, Fernando
Martínez, José-Luis
Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_full Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_fullStr Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_full_unstemmed Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_short Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_sort interventions on metabolism: making antibiotic-susceptible bacteria
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705924/
https://www.ncbi.nlm.nih.gov/pubmed/29184022
http://dx.doi.org/10.1128/mBio.01950-17
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