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Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression

Studies in the MMTV-PyMT (PyMT) breast cancer mouse model have shown a strong influence of the lysosomal cysteine cathepsins B or L on lung metastasis formation. Transgenic expression of human CTSB (tgCTSB) or CTSL (tgCTSL) both led to similar metastatic phenotypes with increased metastatic burden i...

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Detalles Bibliográficos
Autores principales:	Sigloch, Florian Christoph, Tholen, Martina, Gomez-Auli, Alejandro, Biniossek, Martin Lothar, Reinheckel, Thomas, Schilling, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706009/ https://www.ncbi.nlm.nih.gov/pubmed/29187882 http://dx.doi.org/10.7150/jca.21401

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