Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs

Noncoding RNAs play critical roles in regulating protein-coding genes and comprise two major classes: long noncoding RNAs (lncRNAs) and microRNAs (miRNAs). LncRNAs regulate gene expression at transcriptional, post-transcriptional, and epigenetic levels via multiple action modes. LncRNAs can also fun...

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Detalles Bibliográficos
Autores principales: Liu, Wenjing, Ma, Rui, Yuan, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706018/
https://www.ncbi.nlm.nih.gov/pubmed/29187891
http://dx.doi.org/10.7150/jca.22076
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author Liu, Wenjing
Ma, Rui
Yuan, Yuan
author_facet Liu, Wenjing
Ma, Rui
Yuan, Yuan
author_sort Liu, Wenjing
collection PubMed
description Noncoding RNAs play critical roles in regulating protein-coding genes and comprise two major classes: long noncoding RNAs (lncRNAs) and microRNAs (miRNAs). LncRNAs regulate gene expression at transcriptional, post-transcriptional, and epigenetic levels via multiple action modes. LncRNAs can also function as endogenous competitive RNAs for miRNAs and indirectly regulate gene expression post-transcriptionally. By binding to the 3'-untranslated regions (3'-UTR) of target genes, miRNAs post-transcriptionally regulate gene expression. Herein, we conducted a review of post-transcriptional regulation by lncRNAs and miRNAs of genes associated with biological behaviors of gastric cancer.
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spelling pubmed-57060182017-11-29 Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs Liu, Wenjing Ma, Rui Yuan, Yuan J Cancer Review Noncoding RNAs play critical roles in regulating protein-coding genes and comprise two major classes: long noncoding RNAs (lncRNAs) and microRNAs (miRNAs). LncRNAs regulate gene expression at transcriptional, post-transcriptional, and epigenetic levels via multiple action modes. LncRNAs can also function as endogenous competitive RNAs for miRNAs and indirectly regulate gene expression post-transcriptionally. By binding to the 3'-untranslated regions (3'-UTR) of target genes, miRNAs post-transcriptionally regulate gene expression. Herein, we conducted a review of post-transcriptional regulation by lncRNAs and miRNAs of genes associated with biological behaviors of gastric cancer. Ivyspring International Publisher 2017-11-12 /pmc/articles/PMC5706018/ /pubmed/29187891 http://dx.doi.org/10.7150/jca.22076 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Liu, Wenjing
Ma, Rui
Yuan, Yuan
Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs
title Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs
title_full Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs
title_fullStr Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs
title_full_unstemmed Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs
title_short Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs
title_sort post-transcriptional regulation of genes related to biological behaviors of gastric cancer by long noncoding rnas and micrornas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706018/
https://www.ncbi.nlm.nih.gov/pubmed/29187891
http://dx.doi.org/10.7150/jca.22076
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AT yuanyuan posttranscriptionalregulationofgenesrelatedtobiologicalbehaviorsofgastriccancerbylongnoncodingrnasandmicrornas

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