Cargando…

RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition

BACKGROUND: RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition of apoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents. The aim of this study was to investigate its role in chemoresistance of color...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rubio, María Fernanda, Lira, María Cecilia, Rosa, Francisco Damián, Sambresqui, Adrían Dario, Salazar Güemes, María Cecilia, Costas, Mónica Alejandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706160/ https://www.ncbi.nlm.nih.gov/pubmed/29209153 http://dx.doi.org/10.1186/s12935-017-0483-x

Ejemplares similares

Role of RAC3 coactivator in the adipocyte differentiation
por: Lira, María Cecilia, et al.
Publicado: (2018)

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway
por: Liu, Weiguang, et al.
Publicado: (2019)

NCoA3 upregulation in breast cancer‑associated adipocytes elicits an inflammatory profile
por: Lira, María Cecilia, et al.
Publicado: (2023)

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth
por: Liu, Jing, et al.
Publicado: (2019)

The inflammatory cytokine TNF contributes with RAC3-induced malignant transformation
por: Machado, Mileni Soares, et al.
Publicado: (2018)

The levels of RAC3 expression are up regulated by TNF in the inflammatory response
por: Alvarado, Cecilia Viviana, et al.
Publicado: (2014)

YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway
por: Zhou, Yuan, et al.
Publicado: (2019)

The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines
por: Cirigliano, Stéfano M., et al.
Publicado: (2017)

LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells
por: Wang, Xinke, et al.
Publicado: (2019)

Autophagy contributes to apoptosis in A20 and EL4 lymphoma cells treated with fluvastatin
por: Qi, Xu-Feng, et al.
Publicado: (2013)

Prodigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy
por: Zheng, Dijie, et al.
Publicado: (2021)

Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells
por: Lai, Weixin, et al.
Publicado: (2021)

Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis
por: Takahashi, Akimasa, et al.
Publicado: (2014)

SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer
por: Yan, Dewen, et al.
Publicado: (2018)

Marsdenia tenacissima extract induces apoptosis and suppresses autophagy through ERK activation in lung cancer cells
por: Jiao, Yan-Na, et al.
Publicado: (2018)

Dysfunction of apoptosis and autophagy correlates with local recurrence in esophageal squamous cell carcinoma after definitive chemoradiation
por: Qiu, Hu, et al.
Publicado: (2021)

miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor
por: Iida, Keiichiro, et al.
Publicado: (2013)

Integrated analysis of potential pathways by which aloe-emodin induces the apoptosis of colon cancer cells
por: Jiang, Dongxiao, et al.
Publicado: (2021)

Beclin1 inhibition promotes autophagy and decreases gemcitabine–induced apoptosis in Miapaca2 pancreatic cancer cells
por: Li, Xiaoshu, et al.
Publicado: (2013)

Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells
por: Theron, Anne E, et al.
Publicado: (2013)

S-Adenosylmethionine regulates apoptosis and autophagy in MCF-7 breast cancer cells through the modulation of specific microRNAs
por: Ilisso, Concetta Paola, et al.
Publicado: (2018)

Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia
por: Shi, Ce, et al.
Publicado: (2020)

RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric cancer cells
por: Zheng, Zhong, et al.
Publicado: (2015)

Transient knockdown-mediated deficiency in plectin alters hepatocellular motility in association with activated FAK and Rac1-GTPase
por: Cheng, Chiung-Chi, et al.
Publicado: (2015)

The stem cell factor antibody enhances the chemotherapeutic effect of adriamycin on chemoresistant breast cancer cells
por: Jelly, Neil D, et al.
Publicado: (2012)

Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma
por: Wang, Ke, et al.
Publicado: (2017)

Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
por: Zhang, Wei, et al.
Publicado: (2020)

Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy
por: Liu, Yeying, et al.
Publicado: (2019)

2-Methoxyestradiol-bis-sulphamate refrains from inducing apoptosis and autophagy in a non-tumorigenic breast cell line
por: Visagie, Michelle H, et al.
Publicado: (2012)

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer
por: Xie, Biao, et al.
Publicado: (2013)

RAMS11 promotes CRC through mTOR-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition
por: Islam Khan, Md Zahirul, et al.
Publicado: (2021)

Nanos3, a cancer-germline gene, promotes cell proliferation, migration, chemoresistance, and invasion of human glioblastoma
por: Zhang, Fengyu, et al.
Publicado: (2020)

Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance
por: Levin, May, et al.
Publicado: (2021)

High RAC3 expression levels are required for induction and maintaining of cancer cell stemness
por: Panelo, Laura C., et al.
Publicado: (2017)

KIAA0101, a target gene of miR-429, enhances migration and chemoresistance of epithelial ovarian cancer cells
por: Chen, Hong, et al.
Publicado: (2016)

Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway
por: Wu, Zhaojia, et al.
Publicado: (2019)

A role for the NPM1/PTPN14/YAP axis in mediating hypoxia-induced chemoresistance to sorafenib in hepatocellular carcinoma
por: Zhang, Dengke, et al.
Publicado: (2022)

JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4
por: Jing, Chao, et al.
Publicado: (2021)

ERK-mediated autophagy promotes inactivated Sendai virus (HVJ-E)-induced apoptosis in HeLa cells in an Atg3-dependent manner
por: Wang, Tao, et al.
Publicado: (2018)

Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis
por: Scicchitano, Bianca Maria, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1a2gmoajt16qbrdd5apdlujh63