The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse

Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by which opioids relieve pain and induce euphoria is dependent on the drug crossing the blood...

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Detalles Bibliográficos
Autores principales: Schaefer, Charles P., Tome, Margaret E., Davis, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706290/
https://www.ncbi.nlm.nih.gov/pubmed/29183383
http://dx.doi.org/10.1186/s12987-017-0080-3
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author Schaefer, Charles P.
Tome, Margaret E.
Davis, Thomas P.
author_facet Schaefer, Charles P.
Tome, Margaret E.
Davis, Thomas P.
author_sort Schaefer, Charles P.
collection PubMed
description Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by which opioids relieve pain and induce euphoria is dependent on the drug crossing the blood–brain barrier and accessing the central nervous system. This suggests the blood brain barrier plays a central role in both the benefits and risks of opioid use. The complex physiological responses to opioids that provide the benefits and drive the abuse also needs to be considered in the resolution of the opioid epidemic.
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spelling pubmed-57062902017-12-05 The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse Schaefer, Charles P. Tome, Margaret E. Davis, Thomas P. Fluids Barriers CNS Review Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by which opioids relieve pain and induce euphoria is dependent on the drug crossing the blood–brain barrier and accessing the central nervous system. This suggests the blood brain barrier plays a central role in both the benefits and risks of opioid use. The complex physiological responses to opioids that provide the benefits and drive the abuse also needs to be considered in the resolution of the opioid epidemic. BioMed Central 2017-11-29 /pmc/articles/PMC5706290/ /pubmed/29183383 http://dx.doi.org/10.1186/s12987-017-0080-3 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Schaefer, Charles P.
Tome, Margaret E.
Davis, Thomas P.
The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
title The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
title_full The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
title_fullStr The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
title_full_unstemmed The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
title_short The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
title_sort opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706290/
https://www.ncbi.nlm.nih.gov/pubmed/29183383
http://dx.doi.org/10.1186/s12987-017-0080-3
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