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Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2
BACKGROUND: Smad4 is a critical effector of TGF-β signaling that regulates a variety of cellular functions. However, its role in the brain has rarely been studied. Here, we examined the molecular mechanisms underlying the post-translational regulation of Smad4 function by SUMOylation, and its role i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706330/ https://www.ncbi.nlm.nih.gov/pubmed/29183317 http://dx.doi.org/10.1186/s12915-017-0452-9 |