Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

BACKGROUND: While age and the APOE ε4 allele are major risk factors for Alzheimer’s disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline. METHODS: We used over 200 “AD re...

Descripción completa

Detalles Bibliográficos
Autores principales: Ridge, Perry G., Karch, Celeste M., Hsu, Simon, Arano, Ivan, Teerlink, Craig C., Ebbert, Mark T. W., Gonzalez Murcia, Josue D., Farnham, James M., Damato, Anna R., Allen, Mariet, Wang, Xue, Harari, Oscar, Fernandez, Victoria M., Guerreiro, Rita, Bras, Jose, Hardy, John, Munger, Ronald, Norton, Maria, Sassi, Celeste, Singleton, Andrew, Younkin, Steven G., Dickson, Dennis W., Golde, Todd E., Price, Nathan D., Ertekin-Taner, Nilüfer, Cruchaga, Carlos, Goate, Alison M., Corcoran, Christopher, Tschanz, JoAnn, Cannon-Albright, Lisa A., Kauwe, John S. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706401/
https://www.ncbi.nlm.nih.gov/pubmed/29183403
http://dx.doi.org/10.1186/s13073-017-0486-1

Ejemplares similares

Ejemplares similares