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Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking

Retrograde trafficking from the endosomal system through the Golgi apparatus back to the endoplasmic reticulum is an essential pathway in eukaryotic cells, serving to maintain organelle identity and to recycle empty cargo receptors delivered by the secretory pathway. Intracellular replication of sev...

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Autores principales: Bärlocher, Kevin, Welin, Amanda, Hilbi, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706426/
https://www.ncbi.nlm.nih.gov/pubmed/29226112
http://dx.doi.org/10.3389/fcimb.2017.00482
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author Bärlocher, Kevin
Welin, Amanda
Hilbi, Hubert
author_facet Bärlocher, Kevin
Welin, Amanda
Hilbi, Hubert
author_sort Bärlocher, Kevin
collection PubMed
description Retrograde trafficking from the endosomal system through the Golgi apparatus back to the endoplasmic reticulum is an essential pathway in eukaryotic cells, serving to maintain organelle identity and to recycle empty cargo receptors delivered by the secretory pathway. Intracellular replication of several bacterial pathogens, including Legionella pneumophila, is restricted by the retrograde trafficking pathway. L. pneumophila employs the Icm/Dot type IV secretion system (T4SS) to form the replication-permissive Legionella-containing vacuole (LCV), which is decorated with multiple components of the retrograde trafficking machinery as well as retrograde cargo receptors. The L. pneumophila effector protein RidL is secreted by the T4SS and interferes with retrograde trafficking. Here, we review recent evidence that the LCV interacts with the retrograde trafficking pathway, discuss the possible sites of action and function of RidL in the retrograde route, and put forth the hypothesis that the LCV is an acceptor compartment of retrograde transport vesicles.
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spelling pubmed-57064262017-12-08 Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking Bärlocher, Kevin Welin, Amanda Hilbi, Hubert Front Cell Infect Microbiol Microbiology Retrograde trafficking from the endosomal system through the Golgi apparatus back to the endoplasmic reticulum is an essential pathway in eukaryotic cells, serving to maintain organelle identity and to recycle empty cargo receptors delivered by the secretory pathway. Intracellular replication of several bacterial pathogens, including Legionella pneumophila, is restricted by the retrograde trafficking pathway. L. pneumophila employs the Icm/Dot type IV secretion system (T4SS) to form the replication-permissive Legionella-containing vacuole (LCV), which is decorated with multiple components of the retrograde trafficking machinery as well as retrograde cargo receptors. The L. pneumophila effector protein RidL is secreted by the T4SS and interferes with retrograde trafficking. Here, we review recent evidence that the LCV interacts with the retrograde trafficking pathway, discuss the possible sites of action and function of RidL in the retrograde route, and put forth the hypothesis that the LCV is an acceptor compartment of retrograde transport vesicles. Frontiers Media S.A. 2017-11-24 /pmc/articles/PMC5706426/ /pubmed/29226112 http://dx.doi.org/10.3389/fcimb.2017.00482 Text en Copyright © 2017 Bärlocher, Welin and Hilbi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Bärlocher, Kevin
Welin, Amanda
Hilbi, Hubert
Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking
title Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking
title_full Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking
title_fullStr Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking
title_full_unstemmed Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking
title_short Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking
title_sort formation of the legionella replicative compartment at the crossroads of retrograde trafficking
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706426/
https://www.ncbi.nlm.nih.gov/pubmed/29226112
http://dx.doi.org/10.3389/fcimb.2017.00482
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