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Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis

OBJECTIVES: We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated. METHODS: We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the...

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Autores principales: Baudart, Pauline, Louati, Karine, Marcelli, Christian, Berenbaum, Francis, Sellam, Jérémie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RMD Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706481/
https://www.ncbi.nlm.nih.gov/pubmed/29435358
http://dx.doi.org/10.1136/rmdopen-2017-000442
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author Baudart, Pauline
Louati, Karine
Marcelli, Christian
Berenbaum, Francis
Sellam, Jérémie
author_facet Baudart, Pauline
Louati, Karine
Marcelli, Christian
Berenbaum, Francis
Sellam, Jérémie
author_sort Baudart, Pauline
collection PubMed
description OBJECTIVES: We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated. METHODS: We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the number of patients with OA and/or dyslipidemia. We calculated the mean (±SD) prevalence of dyslipidemia in patients with and without OA and the risk of dyslipidemia (OR, 95% CI) among patients with OA. RESULTS: From 605 articles screened, 48 were included in the analysis (describing 29 cross-sectional, 10 cohort and 9 case–control studies). The mean prevalence of dyslipidemia was 30.2%±0.6% among 14 843 patients with OA and 8.0%±0.1% among 196 168 without OA. The risk of dyslipidemia was greater with than without OA overall (OR 1.98,95% CI 1.43 to 2.75, p<0.0001) and with knee OA (OR 2.27, 1.33 to 3.89, p=0.003) and hand OA (OR 2.12, 1.46 to 3.07), p<0.0001). CONCLUSION: The risk of dyslipidemia was twofold greater with than without OA, so lipid disturbances could be a risk factor for OA. Such a result supports the individualisation of the metabolic syndrome-associated OA phenotype.
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spelling pubmed-57064812018-02-12 Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis Baudart, Pauline Louati, Karine Marcelli, Christian Berenbaum, Francis Sellam, Jérémie RMD Open Osteoarthritis OBJECTIVES: We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated. METHODS: We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the number of patients with OA and/or dyslipidemia. We calculated the mean (±SD) prevalence of dyslipidemia in patients with and without OA and the risk of dyslipidemia (OR, 95% CI) among patients with OA. RESULTS: From 605 articles screened, 48 were included in the analysis (describing 29 cross-sectional, 10 cohort and 9 case–control studies). The mean prevalence of dyslipidemia was 30.2%±0.6% among 14 843 patients with OA and 8.0%±0.1% among 196 168 without OA. The risk of dyslipidemia was greater with than without OA overall (OR 1.98,95% CI 1.43 to 2.75, p<0.0001) and with knee OA (OR 2.27, 1.33 to 3.89, p=0.003) and hand OA (OR 2.12, 1.46 to 3.07), p<0.0001). CONCLUSION: The risk of dyslipidemia was twofold greater with than without OA, so lipid disturbances could be a risk factor for OA. Such a result supports the individualisation of the metabolic syndrome-associated OA phenotype. RMD Open 2017-08-29 /pmc/articles/PMC5706481/ /pubmed/29435358 http://dx.doi.org/10.1136/rmdopen-2017-000442 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Osteoarthritis
Baudart, Pauline
Louati, Karine
Marcelli, Christian
Berenbaum, Francis
Sellam, Jérémie
Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
title Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
title_full Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
title_fullStr Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
title_full_unstemmed Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
title_short Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
title_sort association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
topic Osteoarthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706481/
https://www.ncbi.nlm.nih.gov/pubmed/29435358
http://dx.doi.org/10.1136/rmdopen-2017-000442
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