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Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
OBJECTIVES: We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated. METHODS: We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RMD Open
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706481/ https://www.ncbi.nlm.nih.gov/pubmed/29435358 http://dx.doi.org/10.1136/rmdopen-2017-000442 |
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author | Baudart, Pauline Louati, Karine Marcelli, Christian Berenbaum, Francis Sellam, Jérémie |
author_facet | Baudart, Pauline Louati, Karine Marcelli, Christian Berenbaum, Francis Sellam, Jérémie |
author_sort | Baudart, Pauline |
collection | PubMed |
description | OBJECTIVES: We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated. METHODS: We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the number of patients with OA and/or dyslipidemia. We calculated the mean (±SD) prevalence of dyslipidemia in patients with and without OA and the risk of dyslipidemia (OR, 95% CI) among patients with OA. RESULTS: From 605 articles screened, 48 were included in the analysis (describing 29 cross-sectional, 10 cohort and 9 case–control studies). The mean prevalence of dyslipidemia was 30.2%±0.6% among 14 843 patients with OA and 8.0%±0.1% among 196 168 without OA. The risk of dyslipidemia was greater with than without OA overall (OR 1.98,95% CI 1.43 to 2.75, p<0.0001) and with knee OA (OR 2.27, 1.33 to 3.89, p=0.003) and hand OA (OR 2.12, 1.46 to 3.07), p<0.0001). CONCLUSION: The risk of dyslipidemia was twofold greater with than without OA, so lipid disturbances could be a risk factor for OA. Such a result supports the individualisation of the metabolic syndrome-associated OA phenotype. |
format | Online Article Text |
id | pubmed-5706481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | RMD Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-57064812018-02-12 Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis Baudart, Pauline Louati, Karine Marcelli, Christian Berenbaum, Francis Sellam, Jérémie RMD Open Osteoarthritis OBJECTIVES: We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated. METHODS: We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the number of patients with OA and/or dyslipidemia. We calculated the mean (±SD) prevalence of dyslipidemia in patients with and without OA and the risk of dyslipidemia (OR, 95% CI) among patients with OA. RESULTS: From 605 articles screened, 48 were included in the analysis (describing 29 cross-sectional, 10 cohort and 9 case–control studies). The mean prevalence of dyslipidemia was 30.2%±0.6% among 14 843 patients with OA and 8.0%±0.1% among 196 168 without OA. The risk of dyslipidemia was greater with than without OA overall (OR 1.98,95% CI 1.43 to 2.75, p<0.0001) and with knee OA (OR 2.27, 1.33 to 3.89, p=0.003) and hand OA (OR 2.12, 1.46 to 3.07), p<0.0001). CONCLUSION: The risk of dyslipidemia was twofold greater with than without OA, so lipid disturbances could be a risk factor for OA. Such a result supports the individualisation of the metabolic syndrome-associated OA phenotype. RMD Open 2017-08-29 /pmc/articles/PMC5706481/ /pubmed/29435358 http://dx.doi.org/10.1136/rmdopen-2017-000442 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Osteoarthritis Baudart, Pauline Louati, Karine Marcelli, Christian Berenbaum, Francis Sellam, Jérémie Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis |
title | Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis |
title_full | Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis |
title_fullStr | Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis |
title_full_unstemmed | Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis |
title_short | Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis |
title_sort | association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis |
topic | Osteoarthritis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706481/ https://www.ncbi.nlm.nih.gov/pubmed/29435358 http://dx.doi.org/10.1136/rmdopen-2017-000442 |
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