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Telocytes play a key role in prostate tissue organisation during the gland morphogenesis
Telocytes are CD34‐positive interstitial cells, known to exert several functions, one of which is a role in tissue organisation, previously demonstrated by telocytes in the myocardium. The existence of telocytes in the prostate has recently been reported, however, there is a lack of information rega...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706570/ https://www.ncbi.nlm.nih.gov/pubmed/28840644 http://dx.doi.org/10.1111/jcmm.13234 |
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author | Sanches, Bruno D. A. Maldarine, Juliana S. Zani, Bruno C. Tamarindo, Guilherme H. Biancardi, Manoel F. Santos, Fernanda C. A. Rahal, Paula Góes, Rejane M. Felisbino, Sérgio L. Vilamaior, Patricia S. L. Taboga, Sebastião R. |
author_facet | Sanches, Bruno D. A. Maldarine, Juliana S. Zani, Bruno C. Tamarindo, Guilherme H. Biancardi, Manoel F. Santos, Fernanda C. A. Rahal, Paula Góes, Rejane M. Felisbino, Sérgio L. Vilamaior, Patricia S. L. Taboga, Sebastião R. |
author_sort | Sanches, Bruno D. A. |
collection | PubMed |
description | Telocytes are CD34‐positive interstitial cells, known to exert several functions, one of which is a role in tissue organisation, previously demonstrated by telocytes in the myocardium. The existence of telocytes in the prostate has recently been reported, however, there is a lack of information regarding the function of these cells in prostate tissue, and information regarding the possible role of these cells in prostatic development. This study used immunofluorescence techniques in prostate tissue and prostatic telocytes in culture to determine the relationship between telocytes and prostate morphogenesis. Furthermore, immunofluorescent labelling of telocytes was performed on prostate tissue at different stages of early postnatal development. Initially, CD34‐positive cells are found at the periphery of the developing alveoli, later in the same region, c‐kit‐positive cells and cells positive for both factors are verified and CD34‐positive cells were predominantly observed in the interalveolar stroma and the region surrounding the periductal smooth muscle. Fluorescence assays also demonstrated that telocytes secrete TGF‐β1 and are ER‐Beta (ERβ) positive. The results suggest that telocytes play a changing role during development, initially supporting the differentiation of periductal and perialveolar smooth muscle, and later, producing dense networks that separate alveoli groups and form a barrier between the interalveolar region and periurethral smooth muscle. We conclude that telocytes play a relevant role in prostate tissue organisation during postnatal development. |
format | Online Article Text |
id | pubmed-5706570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57065702017-12-06 Telocytes play a key role in prostate tissue organisation during the gland morphogenesis Sanches, Bruno D. A. Maldarine, Juliana S. Zani, Bruno C. Tamarindo, Guilherme H. Biancardi, Manoel F. Santos, Fernanda C. A. Rahal, Paula Góes, Rejane M. Felisbino, Sérgio L. Vilamaior, Patricia S. L. Taboga, Sebastião R. J Cell Mol Med Original Articles Telocytes are CD34‐positive interstitial cells, known to exert several functions, one of which is a role in tissue organisation, previously demonstrated by telocytes in the myocardium. The existence of telocytes in the prostate has recently been reported, however, there is a lack of information regarding the function of these cells in prostate tissue, and information regarding the possible role of these cells in prostatic development. This study used immunofluorescence techniques in prostate tissue and prostatic telocytes in culture to determine the relationship between telocytes and prostate morphogenesis. Furthermore, immunofluorescent labelling of telocytes was performed on prostate tissue at different stages of early postnatal development. Initially, CD34‐positive cells are found at the periphery of the developing alveoli, later in the same region, c‐kit‐positive cells and cells positive for both factors are verified and CD34‐positive cells were predominantly observed in the interalveolar stroma and the region surrounding the periductal smooth muscle. Fluorescence assays also demonstrated that telocytes secrete TGF‐β1 and are ER‐Beta (ERβ) positive. The results suggest that telocytes play a changing role during development, initially supporting the differentiation of periductal and perialveolar smooth muscle, and later, producing dense networks that separate alveoli groups and form a barrier between the interalveolar region and periurethral smooth muscle. We conclude that telocytes play a relevant role in prostate tissue organisation during postnatal development. John Wiley and Sons Inc. 2017-08-24 2017-12 /pmc/articles/PMC5706570/ /pubmed/28840644 http://dx.doi.org/10.1111/jcmm.13234 Text en © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Sanches, Bruno D. A. Maldarine, Juliana S. Zani, Bruno C. Tamarindo, Guilherme H. Biancardi, Manoel F. Santos, Fernanda C. A. Rahal, Paula Góes, Rejane M. Felisbino, Sérgio L. Vilamaior, Patricia S. L. Taboga, Sebastião R. Telocytes play a key role in prostate tissue organisation during the gland morphogenesis |
title | Telocytes play a key role in prostate tissue organisation during the gland morphogenesis |
title_full | Telocytes play a key role in prostate tissue organisation during the gland morphogenesis |
title_fullStr | Telocytes play a key role in prostate tissue organisation during the gland morphogenesis |
title_full_unstemmed | Telocytes play a key role in prostate tissue organisation during the gland morphogenesis |
title_short | Telocytes play a key role in prostate tissue organisation during the gland morphogenesis |
title_sort | telocytes play a key role in prostate tissue organisation during the gland morphogenesis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706570/ https://www.ncbi.nlm.nih.gov/pubmed/28840644 http://dx.doi.org/10.1111/jcmm.13234 |
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