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Pharmacokinetic Properties of DNA Aptamers with Base Modifications

The addition of novel side chains at the 5-position of uracil is an effective means to increase chemical diversity of aptamers and hence the success rate for discovery of high-affinity ligands to protein targets. Such modifications also increase nuclease resistance, which is useful in a range of app...

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Detalles Bibliográficos
Autores principales:	Gupta, Shashi, Drolet, Daniel W., Wolk, Steven K., Waugh, Sheela M., Rohloff, John C., Carter, Jeffery D., Mayfield, Wesley S., Otis, Matthew R., Fowler, Catherine R., Suzuki, Tomoki, Hirota, Masao, Ishikawa, Yuichi, Schneider, Daniel J., Janjic, Nebojsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706628/ https://www.ncbi.nlm.nih.gov/pubmed/28961063 http://dx.doi.org/10.1089/nat.2017.0683

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