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Parallel arrangements of positive feedback loops limit cell-to-cell variability in differentiation
Cellular differentiations are often regulated by bistable switches resulting from specific arrangements of multiple positive feedback loops (PFL) fused to one another. Although bistability generates digital responses at the cellular level, stochasticity in chemical reactions causes population hetero...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706692/ https://www.ncbi.nlm.nih.gov/pubmed/29186174 http://dx.doi.org/10.1371/journal.pone.0188623 |