Cargando…
Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound
To discuss the relationship between the regional cerebral blood flow (rCBF) and cerebral perfusion pressure (CPP) and the effect of CPP on rCBF in different spaces in an experimental animal model. As the ICP increased, the CPP and rCBF (A × β value measured by CEU) decreased to varying degrees. The...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706802/ https://www.ncbi.nlm.nih.gov/pubmed/29212156 http://dx.doi.org/10.18632/oncotarget.21795 |
_version_ | 1783282288047423488 |
---|---|
author | Cheng, Hongwei Mao, Xiang Hou, Zonggang Xu, Jian Hao, Shuyu Li, Huan Liu, Baiyun |
author_facet | Cheng, Hongwei Mao, Xiang Hou, Zonggang Xu, Jian Hao, Shuyu Li, Huan Liu, Baiyun |
author_sort | Cheng, Hongwei |
collection | PubMed |
description | To discuss the relationship between the regional cerebral blood flow (rCBF) and cerebral perfusion pressure (CPP) and the effect of CPP on rCBF in different spaces in an experimental animal model. As the ICP increased, the CPP and rCBF (A × β value measured by CEU) decreased to varying degrees. The rCBF(1) and rCBF(2) were well correlated with the CPP. At the same CPP, rCBF(1) decreased significantly than the level of rCBF(2) (p < 0.01). Six healthy cross-breed dogs, both males and females, weighing 18.3 ± 1.6 kg, were selected to establish models of increased intracranial pressure (ICP) via the installation of an epidural latex sacculus. The calculated CPP was in accordance with the ICP through the formula CPP = MAP - ICP, and contrast-enhanced ultrasound (CEU) was used to instantly measure the rCBF 1 and 2 cm around the sacculus edge. The relationship between rCBF 1 cm (rCBF(1)) and 2 cm (rCBF(2)) around the sacculus edge and the CPP was analyzed. As the ICP increased, the CPP and rCBF both decreased. The rCBF and the CPP had a linear relationship, but the perfusion pressure did not necessarily determine all parts of the rCBF. The rCBF was different in different spaces: the farther away from the injured site, the smaller the effect on the rCBF. |
format | Online Article Text |
id | pubmed-5706802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57068022017-12-05 Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound Cheng, Hongwei Mao, Xiang Hou, Zonggang Xu, Jian Hao, Shuyu Li, Huan Liu, Baiyun Oncotarget Research Paper: Pathology To discuss the relationship between the regional cerebral blood flow (rCBF) and cerebral perfusion pressure (CPP) and the effect of CPP on rCBF in different spaces in an experimental animal model. As the ICP increased, the CPP and rCBF (A × β value measured by CEU) decreased to varying degrees. The rCBF(1) and rCBF(2) were well correlated with the CPP. At the same CPP, rCBF(1) decreased significantly than the level of rCBF(2) (p < 0.01). Six healthy cross-breed dogs, both males and females, weighing 18.3 ± 1.6 kg, were selected to establish models of increased intracranial pressure (ICP) via the installation of an epidural latex sacculus. The calculated CPP was in accordance with the ICP through the formula CPP = MAP - ICP, and contrast-enhanced ultrasound (CEU) was used to instantly measure the rCBF 1 and 2 cm around the sacculus edge. The relationship between rCBF 1 cm (rCBF(1)) and 2 cm (rCBF(2)) around the sacculus edge and the CPP was analyzed. As the ICP increased, the CPP and rCBF both decreased. The rCBF and the CPP had a linear relationship, but the perfusion pressure did not necessarily determine all parts of the rCBF. The rCBF was different in different spaces: the farther away from the injured site, the smaller the effect on the rCBF. Impact Journals LLC 2017-10-11 /pmc/articles/PMC5706802/ /pubmed/29212156 http://dx.doi.org/10.18632/oncotarget.21795 Text en Copyright: © 2017 Cheng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper: Pathology Cheng, Hongwei Mao, Xiang Hou, Zonggang Xu, Jian Hao, Shuyu Li, Huan Liu, Baiyun Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound |
title | Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound |
title_full | Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound |
title_fullStr | Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound |
title_full_unstemmed | Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound |
title_short | Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound |
title_sort | effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound |
topic | Research Paper: Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706802/ https://www.ncbi.nlm.nih.gov/pubmed/29212156 http://dx.doi.org/10.18632/oncotarget.21795 |
work_keys_str_mv | AT chenghongwei effectsofcerebralperfusionpressureonregionalcerebralbloodflowindogswithacuteepiduralhematomaquantitativeevaluationwithcontrastenhancedultrasound AT maoxiang effectsofcerebralperfusionpressureonregionalcerebralbloodflowindogswithacuteepiduralhematomaquantitativeevaluationwithcontrastenhancedultrasound AT houzonggang effectsofcerebralperfusionpressureonregionalcerebralbloodflowindogswithacuteepiduralhematomaquantitativeevaluationwithcontrastenhancedultrasound AT xujian effectsofcerebralperfusionpressureonregionalcerebralbloodflowindogswithacuteepiduralhematomaquantitativeevaluationwithcontrastenhancedultrasound AT haoshuyu effectsofcerebralperfusionpressureonregionalcerebralbloodflowindogswithacuteepiduralhematomaquantitativeevaluationwithcontrastenhancedultrasound AT lihuan effectsofcerebralperfusionpressureonregionalcerebralbloodflowindogswithacuteepiduralhematomaquantitativeevaluationwithcontrastenhancedultrasound AT liubaiyun effectsofcerebralperfusionpressureonregionalcerebralbloodflowindogswithacuteepiduralhematomaquantitativeevaluationwithcontrastenhancedultrasound |