Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies

Many cancer cells rely on glutamine as the source of carbon molecules to feed the biosynthetic pathways and are often addicted to glutaminolysis. Inhibitors of glutaminase activity have gained attention in the last few years due to their anti-proliferative effect and ability to induce apoptosis in s...

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Detalles Bibliográficos
Autores principales: Sheikh, Tahir N., Patwardhan, Parag P., Cremers, Serge, Schwartz, Gary K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706855/
https://www.ncbi.nlm.nih.gov/pubmed/29212209
http://dx.doi.org/10.18632/oncotarget.21573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706855/
https://www.ncbi.nlm.nih.gov/pubmed/29212209
http://dx.doi.org/10.18632/oncotarget.21573

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