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Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies
Many cancer cells rely on glutamine as the source of carbon molecules to feed the biosynthetic pathways and are often addicted to glutaminolysis. Inhibitors of glutaminase activity have gained attention in the last few years due to their anti-proliferative effect and ability to induce apoptosis in s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706855/ https://www.ncbi.nlm.nih.gov/pubmed/29212209 http://dx.doi.org/10.18632/oncotarget.21573 |