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Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells

BIRC5 encodes the protein survivin, a member of the inhibitor of apoptosis family. Survivin is highly expressed in a variety of cancers but has very low expression in the corresponding normal tissues, and its expression is often associated with tumor metastasis and chemoresistance. We report that su...

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Detalles Bibliográficos
Autores principales:	Zhao, Guannan, Wang, Qinghui, Gu, Qingqing, Qiang, Wenan, Wei, Jian-Jun, Dong, Peixin, Watari, Hidemichi, Li, Wei, Yue, Junming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706903/ https://www.ncbi.nlm.nih.gov/pubmed/29212257 http://dx.doi.org/10.18632/oncotarget.21863

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