(18)F-Fluoromisonidazole in tumor hypoxia imaging

Hypoxia is a common feature of solid tumors that is closely associated with radiotherapy and chemotherapy resistance, metastasis and tumors prognosis. Thus, it is important to assess hypoxia in tumors for estimating prognosis and selecting appropriate treatment procedures. (18)F-Fluoromisonidazole p...

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Detalles Bibliográficos
Autores principales: Xu, Zuoyu, Li, Xiao-Feng, Zou, Hongyan, Sun, Xilin, Shen, Baozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706929/
https://www.ncbi.nlm.nih.gov/pubmed/29212283
http://dx.doi.org/10.18632/oncotarget.21662
Descripción
Sumario:Hypoxia is a common feature of solid tumors that is closely associated with radiotherapy and chemotherapy resistance, metastasis and tumors prognosis. Thus, it is important to assess hypoxia in tumors for estimating prognosis and selecting appropriate treatment procedures. (18)F-Fluoromisonidazole positron emission tomography ((18)F-FMISO PET) has been widely used to visualize tumor hypoxia in a comprehensive and noninvasive way, both in the clinical and preclinical settings. Here we review the concept, mechanisms and detection methods of tumor hypoxia. Furthermore, we discuss the correlation between (18)F-FMISO PET and other detection methods, current applications of (18)F-FMISO PET and the development prospects of this imaging technology.

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