Some assembly required: Redefining the mitotic checkpoint

The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system monitors kinetochore attachment and spindle assembl...

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Detalles Bibliográficos
Autores principales: Meadows, John C., Millar, Jonathan B. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706941/
https://www.ncbi.nlm.nih.gov/pubmed/29209640
http://dx.doi.org/10.1080/23723556.2017.1314238
Descripción
Sumario:The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system monitors kinetochore attachment and spindle assembly by two distinct, but functionally overlapping, pathways.

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