Some assembly required: Redefining the mitotic checkpoint

The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system monitors kinetochore attachment and spindle assembl...

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Detalles Bibliográficos
Autores principales: Meadows, John C., Millar, Jonathan B. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706941/
https://www.ncbi.nlm.nih.gov/pubmed/29209640
http://dx.doi.org/10.1080/23723556.2017.1314238
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author Meadows, John C.
Millar, Jonathan B. A.
author_facet Meadows, John C.
Millar, Jonathan B. A.
author_sort Meadows, John C.
collection PubMed
description The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system monitors kinetochore attachment and spindle assembly by two distinct, but functionally overlapping, pathways.
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spelling pubmed-57069412018-04-12 Some assembly required: Redefining the mitotic checkpoint Meadows, John C. Millar, Jonathan B. A. Mol Cell Oncol Commentary The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system monitors kinetochore attachment and spindle assembly by two distinct, but functionally overlapping, pathways. Taylor & Francis 2017-04-12 /pmc/articles/PMC5706941/ /pubmed/29209640 http://dx.doi.org/10.1080/23723556.2017.1314238 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Meadows, John C.
Millar, Jonathan B. A.
Some assembly required: Redefining the mitotic checkpoint
title Some assembly required: Redefining the mitotic checkpoint
title_full Some assembly required: Redefining the mitotic checkpoint
title_fullStr Some assembly required: Redefining the mitotic checkpoint
title_full_unstemmed Some assembly required: Redefining the mitotic checkpoint
title_short Some assembly required: Redefining the mitotic checkpoint
title_sort some assembly required: redefining the mitotic checkpoint
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706941/
https://www.ncbi.nlm.nih.gov/pubmed/29209640
http://dx.doi.org/10.1080/23723556.2017.1314238
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