NRAS-driven melanoma: A RAF can hide another

Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, hi...

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Detalles Bibliográficos
Autores principales: Druillennec, Sabine, Pouponnot, Celio, Eychène, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706944/
https://www.ncbi.nlm.nih.gov/pubmed/29209643
http://dx.doi.org/10.1080/23723556.2017.1344758
Descripción
Sumario:Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, highlighting an addiction to RAF signaling in NRAS-driven melanoma.

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