NRAS-driven melanoma: A RAF can hide another

Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, hi...

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Autores principales: Druillennec, Sabine, Pouponnot, Celio, Eychène, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706944/
https://www.ncbi.nlm.nih.gov/pubmed/29209643
http://dx.doi.org/10.1080/23723556.2017.1344758
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author Druillennec, Sabine
Pouponnot, Celio
Eychène, Alain
author_facet Druillennec, Sabine
Pouponnot, Celio
Eychène, Alain
author_sort Druillennec, Sabine
collection PubMed
description Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, highlighting an addiction to RAF signaling in NRAS-driven melanoma.
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spelling pubmed-57069442018-07-05 NRAS-driven melanoma: A RAF can hide another Druillennec, Sabine Pouponnot, Celio Eychène, Alain Mol Cell Oncol Author's View Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, highlighting an addiction to RAF signaling in NRAS-driven melanoma. Taylor & Francis 2017-07-05 /pmc/articles/PMC5706944/ /pubmed/29209643 http://dx.doi.org/10.1080/23723556.2017.1344758 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Druillennec, Sabine
Pouponnot, Celio
Eychène, Alain
NRAS-driven melanoma: A RAF can hide another
title NRAS-driven melanoma: A RAF can hide another
title_full NRAS-driven melanoma: A RAF can hide another
title_fullStr NRAS-driven melanoma: A RAF can hide another
title_full_unstemmed NRAS-driven melanoma: A RAF can hide another
title_short NRAS-driven melanoma: A RAF can hide another
title_sort nras-driven melanoma: a raf can hide another
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706944/
https://www.ncbi.nlm.nih.gov/pubmed/29209643
http://dx.doi.org/10.1080/23723556.2017.1344758
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