Sestrin1, a tumor suppressor that can be rescued

SESTRIN1 is a tumor suppressor in follicular lymphoma that controls mTORC1 activity and it is inactivated by chromosomal deletions or epigenetically silenced by mutant EZH2(Y641X). Pharmacological inhibition of EZH2 promotes SESTRIN1 re-expression and it restores its tumor suppressive activity, sugg...

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Detalles Bibliográficos
Autores principales: Donaldson, Maria C., Katanayeva, Natalya, Oricchio, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706952/
https://www.ncbi.nlm.nih.gov/pubmed/29209652
http://dx.doi.org/10.1080/23723556.2017.1365107
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author Donaldson, Maria C.
Katanayeva, Natalya
Oricchio, Elisa
author_facet Donaldson, Maria C.
Katanayeva, Natalya
Oricchio, Elisa
author_sort Donaldson, Maria C.
collection PubMed
description SESTRIN1 is a tumor suppressor in follicular lymphoma that controls mTORC1 activity and it is inactivated by chromosomal deletions or epigenetically silenced by mutant EZH2(Y641X). Pharmacological inhibition of EZH2 promotes SESTRIN1 re-expression and it restores its tumor suppressive activity, suggesting the possibility to epigenetically control mTORC1 activity.
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spelling pubmed-57069522018-09-21 Sestrin1, a tumor suppressor that can be rescued Donaldson, Maria C. Katanayeva, Natalya Oricchio, Elisa Mol Cell Oncol Author's View SESTRIN1 is a tumor suppressor in follicular lymphoma that controls mTORC1 activity and it is inactivated by chromosomal deletions or epigenetically silenced by mutant EZH2(Y641X). Pharmacological inhibition of EZH2 promotes SESTRIN1 re-expression and it restores its tumor suppressive activity, suggesting the possibility to epigenetically control mTORC1 activity. Taylor & Francis 2017-09-21 /pmc/articles/PMC5706952/ /pubmed/29209652 http://dx.doi.org/10.1080/23723556.2017.1365107 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Donaldson, Maria C.
Katanayeva, Natalya
Oricchio, Elisa
Sestrin1, a tumor suppressor that can be rescued
title Sestrin1, a tumor suppressor that can be rescued
title_full Sestrin1, a tumor suppressor that can be rescued
title_fullStr Sestrin1, a tumor suppressor that can be rescued
title_full_unstemmed Sestrin1, a tumor suppressor that can be rescued
title_short Sestrin1, a tumor suppressor that can be rescued
title_sort sestrin1, a tumor suppressor that can be rescued
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706952/
https://www.ncbi.nlm.nih.gov/pubmed/29209652
http://dx.doi.org/10.1080/23723556.2017.1365107
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