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Sestrin1, a tumor suppressor that can be rescued

SESTRIN1 is a tumor suppressor in follicular lymphoma that controls mTORC1 activity and it is inactivated by chromosomal deletions or epigenetically silenced by mutant EZH2(Y641X). Pharmacological inhibition of EZH2 promotes SESTRIN1 re-expression and it restores its tumor suppressive activity, sugg...

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Detalles Bibliográficos
Autores principales:	Donaldson, Maria C., Katanayeva, Natalya, Oricchio, Elisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706952/ https://www.ncbi.nlm.nih.gov/pubmed/29209652 http://dx.doi.org/10.1080/23723556.2017.1365107

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