Linking H1 with chromatin and growth control

The retinoblastoma protein (pRb) is considered to be one of the key regulators of cell proliferation. Here we describe our recent findings that linker histone H1.2 is an interaction partner for pRb and impacts upon the genome-wide chromatin binding properties of pRb. Consequently, H1.2 influences tr...

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Detalles Bibliográficos
Autores principales: Munro, Shonagh, La Thangue, Nicholas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706956/
https://www.ncbi.nlm.nih.gov/pubmed/29209648
http://dx.doi.org/10.1080/23723556.2017.1360977
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author Munro, Shonagh
La Thangue, Nicholas B.
author_facet Munro, Shonagh
La Thangue, Nicholas B.
author_sort Munro, Shonagh
collection PubMed
description The retinoblastoma protein (pRb) is considered to be one of the key regulators of cell proliferation. Here we describe our recent findings that linker histone H1.2 is an interaction partner for pRb and impacts upon the genome-wide chromatin binding properties of pRb. Consequently, H1.2 influences transcriptional repression and cell cycle control.
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spelling pubmed-57069562018-09-21 Linking H1 with chromatin and growth control Munro, Shonagh La Thangue, Nicholas B. Mol Cell Oncol Author's View The retinoblastoma protein (pRb) is considered to be one of the key regulators of cell proliferation. Here we describe our recent findings that linker histone H1.2 is an interaction partner for pRb and impacts upon the genome-wide chromatin binding properties of pRb. Consequently, H1.2 influences transcriptional repression and cell cycle control. Taylor & Francis 2017-09-21 /pmc/articles/PMC5706956/ /pubmed/29209648 http://dx.doi.org/10.1080/23723556.2017.1360977 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Munro, Shonagh
La Thangue, Nicholas B.
Linking H1 with chromatin and growth control
title Linking H1 with chromatin and growth control
title_full Linking H1 with chromatin and growth control
title_fullStr Linking H1 with chromatin and growth control
title_full_unstemmed Linking H1 with chromatin and growth control
title_short Linking H1 with chromatin and growth control
title_sort linking h1 with chromatin and growth control
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706956/
https://www.ncbi.nlm.nih.gov/pubmed/29209648
http://dx.doi.org/10.1080/23723556.2017.1360977
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