Cargando…

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous insights into the pathology and aid in the design of compounds t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodriguez Camargo, Diana C, Korshavn, Kyle J, Jussupow, Alexander, Raltchev, Kolio, Goricanec, David, Fleisch, Markus, Sarkar, Riddhiman, Xue, Kai, Aichler, Michaela, Mettenleiter, Gabriele, Walch, Axel Karl, Camilloni, Carlo, Hagn, Franz, Reif, Bernd, Ramamoorthy, Ayyalusamy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706959/ https://www.ncbi.nlm.nih.gov/pubmed/29148426 http://dx.doi.org/10.7554/eLife.31226

Ejemplares similares

The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes
por: Rodriguez Camargo, Diana C., et al.
Publicado: (2017)

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity
por: Krotee, Pascal, et al.
Publicado: (2017)

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice
por: Franko, Andras, et al.
Publicado: (2018)

Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action
por: Niu, Zheng, et al.
Publicado: (2020)

Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation
por: Mo, Yuxiang, et al.
Publicado: (2016)

Effect of DNA Origami Nanostructures on hIAPP Aggregation
por: Hanke, Marcel, et al.
Publicado: (2020)

Bleomycin modulates amyloid aggregation in β-amyloid and hIAPP
por: Kumari, Anchala, et al.
Publicado: (2020)

Metastable intermediate during hIAPP aggregation catalyzed by membranes as detected with 2D IR spectroscopy
por: Dicke, Sidney S., et al.
Publicado: (2022)

Effect of Terminal Modifications on the Adsorption and Assembly of hIAPP(20–29)
por: Hajiraissi, Roozbeh, et al.
Publicado: (2019)

Factors That Contribute to hIAPP Amyloidosis in Type 2 Diabetes Mellitus
por: Sevcuka, Adriana, et al.
Publicado: (2022)

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
por: Abedini, Andisheh, et al.
Publicado: (2016)

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics
por: Hernández, Miriam García, et al.
Publicado: (2018)

Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly
por: Xu, Yong, et al.
Publicado: (2022)

Nanoscale Surface Topography Modulates hIAPP Aggregation Pathways at Solid–Liquid Interfaces
por: Hanke, Marcel, et al.
Publicado: (2021)

The Effect of Calcium Ions on hIAPP Channel Activity: Possible Implications in T2DM
por: Meleleo, Daniela, et al.
Publicado: (2023)

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives
por: Pithadia, Amit, et al.
Publicado: (2016)

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
por: Mishra, Aseem, et al.
Publicado: (2013)

A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP
por: Shi, Yue, et al.
Publicado: (2019)

β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation
por: Lesma, Jacopo, et al.
Publicado: (2021)

Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective
por: Hassan, Shahab, et al.
Publicado: (2022)

Diabetes Drug Discovery: hIAPP(1–37) Polymorphic Amyloid Structures as Novel Therapeutic Targets
por: Fernández-Gómez, Isaac, et al.
Publicado: (2018)

Chitosan Oligosaccharides Attenuate Amyloid Formation of hIAPP and Protect Pancreatic β-Cells from Cytotoxicity
por: Meng, Qin-Yu, et al.
Publicado: (2020)

Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model
por: Bram, Yaron, et al.
Publicado: (2017)

High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice
por: Xi, Xiao-Xia, et al.
Publicado: (2019)

Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes
por: Bortoletto, Angelina S., et al.
Publicado: (2022)

Site-specific single point mutation by anthranilic acid in hIAPP(8–37) enhances anti-amyloidogenic activity
por: Kalita, Sourav, et al.
Publicado: (2021)

Adsorption and Orientation of Human Islet Amyloid Polypeptide (hIAPP) Monomer at Anionic Lipid Bilayers: Implications for Membrane-Mediated Aggregation
por: Jia, Yan, et al.
Publicado: (2013)

Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway
por: Lin, Jianzhen, et al.
Publicado: (2019)

Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity
por: Paul, Ashim, et al.
Publicado: (2020)

Protein-conformational diseases in childhood: Naturally-occurring hIAPP amyloid-oligomers and early β-cell damage in obesity and diabetes
por: Altamirano-Bustamante, Nelly F., et al.
Publicado: (2020)

Bacterial curli protein promotes the conversion of PAP(248-286) into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences
por: Hartman, Kevin, et al.
Publicado: (2013)

Human Islet Amyloid Polypeptide Transgenic Mice: In Vivo and Ex Vivo Models for the Role of hIAPP in Type 2 Diabetes Mellitus
por: Höppener, J. W. M., et al.
Publicado: (2008)

Atomic structure of a mitochondrial complex I intermediate from vascular plants
por: Maldonado, Maria, et al.
Publicado: (2020)

Mechanistic Insights into the Polymorphic Associations and Cross-Seeding of Aβ and hIAPP in the Presence of Histidine Tautomerism: An All-Atom Molecular Dynamic Study
por: Salimi, Abbas, et al.
Publicado: (2022)

Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
por: Bortoletto, Angelina S., et al.
Publicado: (2022)

Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway
por: Chim, Nicholas, et al.
Publicado: (2018)

Site-specific detection of protein secondary structure using 2D IR dihedral indexing: a proposed assembly mechanism of oligomeric hIAPP
por: Maj, Michał, et al.
Publicado: (2017)

Unpacking the aggregation-oligomerization-fibrillization process of naturally-occurring hIAPP amyloid oligomers isolated directly from sera of children with obesity or diabetes mellitus
por: Altamirano-Bustamante, Myriam M., et al.
Publicado: (2019)

Modulation of the Conformational Space of SARS‐CoV‐2 RNA Quadruplex RG‐1 by Cellular Components and the Amyloidogenic Peptides α‐Synuclein and hIAPP
por: Mukherjee, Sanjib K., et al.
Publicado: (2022)

Melatonin Inhibits hIAPP Oligomerization by Preventing β-Sheet and Hydrogen Bond Formation of the Amyloidogenic Region Revealed by Replica-Exchange Molecular Dynamics Simulation
por: Wang, Gang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vspv1f57iodcdopdrqp074bmvn