Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

The fidelity of chromosome segregation in mitosis is safeguarded by the precise regulation of kinetochore microtubule (k-MT) attachment stability. Previously, we demonstrated that Cyclin A/Cdk1 destabilizes k-MT attachments to promote faithful chromosome segregation. Here, we use quantitative phosph...

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Detalles Bibliográficos
Autores principales: Dumitru, Ana Maria G, Rusin, Scott F, Clark, Amber E M, Kettenbach, Arminja N, Compton, Duane A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706962/
https://www.ncbi.nlm.nih.gov/pubmed/29154753
http://dx.doi.org/10.7554/eLife.29303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706962/
https://www.ncbi.nlm.nih.gov/pubmed/29154753
http://dx.doi.org/10.7554/eLife.29303

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