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The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate

Solid tumours vary in sensitivity to the vascular disrupting agent combretastatin A-4 3-O-phosphate (CA4P), but underlying factors are poorly understood. The signaling sphingolipid, sphingosine-1-phosphate (S1P), promotes vascular barrier integrity by promoting assembly of VE-cadherin/β-catenin comp...

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Detalles Bibliográficos
Autores principales:	Shepherd, Joanna, Fisher, Matthew, Welford, Abigail, McDonald, Donald M., Kanthou, Chryso, Tozer, Gillian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707050/ https://www.ncbi.nlm.nih.gov/pubmed/29221156 http://dx.doi.org/10.18632/oncotarget.21172

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