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Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells

LB-100 is a novel PP2A inhibitor. Its activity in human colorectal cancer (CRC) cells was tested. The in vitro studies demonstrated that LB-100 inhibited survival and proliferation of both established CRC cells (HCT-116 and HT-29 lines) and primary human colon cancer cells. Further, LB-100 activated...

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Detalles Bibliográficos
Autores principales:	Dai, Cuiping, Zhang, Xuning, Xie, Da, Tang, Peipei, Li, Chunmei, Zuo, Yi, Jiang, Baofei, Xue, Caiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707063/ https://www.ncbi.nlm.nih.gov/pubmed/29221169 http://dx.doi.org/10.18632/oncotarget.21336

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