Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population

Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported...

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Detalles Bibliográficos
Autores principales: Wu, X.T., Hong, P.W., Suolang, D.J., Zhou, D., Stefan, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707210/
https://www.ncbi.nlm.nih.gov/pubmed/29204346
http://dx.doi.org/10.1016/j.ebcr.2017.06.003
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author Wu, X.T.
Hong, P.W.
Suolang, D.J.
Zhou, D.
Stefan, H.
author_facet Wu, X.T.
Hong, P.W.
Suolang, D.J.
Zhou, D.
Stefan, H.
author_sort Wu, X.T.
collection PubMed
description Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy. Understanding the risk associated with VPA-induced DRESS, and taking effective measures to avoid the severe side effects are necessary.
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spelling pubmed-57072102017-12-04 Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population Wu, X.T. Hong, P.W. Suolang, D.J. Zhou, D. Stefan, H. Epilepsy Behav Case Rep Article Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy. Understanding the risk associated with VPA-induced DRESS, and taking effective measures to avoid the severe side effects are necessary. Elsevier 2017-06-20 /pmc/articles/PMC5707210/ /pubmed/29204346 http://dx.doi.org/10.1016/j.ebcr.2017.06.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wu, X.T.
Hong, P.W.
Suolang, D.J.
Zhou, D.
Stefan, H.
Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population
title Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population
title_full Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population
title_fullStr Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population
title_full_unstemmed Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population
title_short Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population
title_sort drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: first case report in asian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707210/
https://www.ncbi.nlm.nih.gov/pubmed/29204346
http://dx.doi.org/10.1016/j.ebcr.2017.06.003
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