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Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial

Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson’s disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, af...

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Autores principales: Díez-Cirarda, María, Ojeda, Natalia, Peña, Javier, Cabrera-Zubizarreta, Alberto, Lucas-Jiménez, Olaia, Gómez-Esteban, Juan Carlos, Gómez-Beldarrain, Maria Ángeles, Ibarretxe-Bilbao, Naroa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707237/
https://www.ncbi.nlm.nih.gov/pubmed/27757820
http://dx.doi.org/10.1007/s11682-016-9639-x
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author Díez-Cirarda, María
Ojeda, Natalia
Peña, Javier
Cabrera-Zubizarreta, Alberto
Lucas-Jiménez, Olaia
Gómez-Esteban, Juan Carlos
Gómez-Beldarrain, Maria Ángeles
Ibarretxe-Bilbao, Naroa
author_facet Díez-Cirarda, María
Ojeda, Natalia
Peña, Javier
Cabrera-Zubizarreta, Alberto
Lucas-Jiménez, Olaia
Gómez-Esteban, Juan Carlos
Gómez-Beldarrain, Maria Ángeles
Ibarretxe-Bilbao, Naroa
author_sort Díez-Cirarda, María
collection PubMed
description Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson’s disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy). T1-weighted, diffusion weighted and functional magnetic resonance images (fMRI) during resting-state and during a memory paradigm (with learning and recognition tasks) were acquired at pre-treatment and post-treatment. Cerebral changes were assessed with repeated measures ANOVA 2 × 2 for group x time interaction. During resting-state fMRI, the REHACOP group showed significantly increased brain connectivity between the left inferior temporal lobe and the bilateral dorsolateral prefrontal cortex compared to the control group. Moreover, during the recognition fMRI task, the REHACOP group showed significantly increased brain activation in the left middle temporal area compared to the control group. During the learning fMRI task, the REHACOP group showed increased brain activation in the left inferior frontal lobe at post-treatment compared to pre-treatment. No significant structural changes were found between pre- and post-treatment. Finally, the REHACOP group showed significant and positive correlations between the brain connectivity and activation and the cognitive performance at post-treatment. This randomized controlled trial suggests that an integrative cognitive rehabilitation program can produce significant functional cerebral changes in PD patients and adds evidence to the efficacy of cognitive rehabilitation programs in the therapeutic approach for PD.
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spelling pubmed-57072372017-12-04 Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial Díez-Cirarda, María Ojeda, Natalia Peña, Javier Cabrera-Zubizarreta, Alberto Lucas-Jiménez, Olaia Gómez-Esteban, Juan Carlos Gómez-Beldarrain, Maria Ángeles Ibarretxe-Bilbao, Naroa Brain Imaging Behav Original Research Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson’s disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy). T1-weighted, diffusion weighted and functional magnetic resonance images (fMRI) during resting-state and during a memory paradigm (with learning and recognition tasks) were acquired at pre-treatment and post-treatment. Cerebral changes were assessed with repeated measures ANOVA 2 × 2 for group x time interaction. During resting-state fMRI, the REHACOP group showed significantly increased brain connectivity between the left inferior temporal lobe and the bilateral dorsolateral prefrontal cortex compared to the control group. Moreover, during the recognition fMRI task, the REHACOP group showed significantly increased brain activation in the left middle temporal area compared to the control group. During the learning fMRI task, the REHACOP group showed increased brain activation in the left inferior frontal lobe at post-treatment compared to pre-treatment. No significant structural changes were found between pre- and post-treatment. Finally, the REHACOP group showed significant and positive correlations between the brain connectivity and activation and the cognitive performance at post-treatment. This randomized controlled trial suggests that an integrative cognitive rehabilitation program can produce significant functional cerebral changes in PD patients and adds evidence to the efficacy of cognitive rehabilitation programs in the therapeutic approach for PD. Springer US 2016-10-18 2017 /pmc/articles/PMC5707237/ /pubmed/27757820 http://dx.doi.org/10.1007/s11682-016-9639-x Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Díez-Cirarda, María
Ojeda, Natalia
Peña, Javier
Cabrera-Zubizarreta, Alberto
Lucas-Jiménez, Olaia
Gómez-Esteban, Juan Carlos
Gómez-Beldarrain, Maria Ángeles
Ibarretxe-Bilbao, Naroa
Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial
title Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial
title_full Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial
title_fullStr Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial
title_full_unstemmed Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial
title_short Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial
title_sort increased brain connectivity and activation after cognitive rehabilitation in parkinson’s disease: a randomized controlled trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707237/
https://www.ncbi.nlm.nih.gov/pubmed/27757820
http://dx.doi.org/10.1007/s11682-016-9639-x
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