Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides

Guanine-rich oligonucleotides (GROs) have attracted considerable attention as anticancer agents, because they exhibit cancer-selective antiproliferative activity and can form G-quadruplex structures with higher nuclease resistance and cellular uptake. Recently, a GRO, AS1411 has reached phase II cli...

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Detalles Bibliográficos
Autores principales: Zhang, Nan, Bing, Tao, Liu, Xiangjun, Qi, Cui, Shen, Luyao, Wang, Linlin, Shangguan, Dihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707456/
https://www.ncbi.nlm.nih.gov/pubmed/29218153
http://dx.doi.org/10.1039/c4sc03949a

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