Hyperpolarization of amino acid derivatives in water for biological applications

We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% (13)C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompa...

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Detalles Bibliográficos
Autores principales: Glöggler, S., Wagner, S., Bouchard, L.-S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707458/
https://www.ncbi.nlm.nih.gov/pubmed/29218193
http://dx.doi.org/10.1039/c5sc00503e
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author Glöggler, S.
Wagner, S.
Bouchard, L.-S.
author_facet Glöggler, S.
Wagner, S.
Bouchard, L.-S.
author_sort Glöggler, S.
collection PubMed
description We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% (13)C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.
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spelling pubmed-57074582017-12-07 Hyperpolarization of amino acid derivatives in water for biological applications Glöggler, S. Wagner, S. Bouchard, L.-S. Chem Sci Chemistry We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% (13)C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity. Royal Society of Chemistry 2015-07-01 2015-05-26 /pmc/articles/PMC5707458/ /pubmed/29218193 http://dx.doi.org/10.1039/c5sc00503e Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Glöggler, S.
Wagner, S.
Bouchard, L.-S.
Hyperpolarization of amino acid derivatives in water for biological applications
title Hyperpolarization of amino acid derivatives in water for biological applications
title_full Hyperpolarization of amino acid derivatives in water for biological applications
title_fullStr Hyperpolarization of amino acid derivatives in water for biological applications
title_full_unstemmed Hyperpolarization of amino acid derivatives in water for biological applications
title_short Hyperpolarization of amino acid derivatives in water for biological applications
title_sort hyperpolarization of amino acid derivatives in water for biological applications
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707458/
https://www.ncbi.nlm.nih.gov/pubmed/29218193
http://dx.doi.org/10.1039/c5sc00503e
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