Organocatalytic asymmetric chlorinative dearomatization of naphthols

An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction cond...

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Detalles Bibliográficos
Autores principales: Yin, Qin, Wang, Shou-Guo, Liang, Xiao-Wei, Gao, De-Wei, Zheng, Jun, You, Shu-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707459/
https://www.ncbi.nlm.nih.gov/pubmed/29218183
http://dx.doi.org/10.1039/c5sc00494b
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author Yin, Qin
Wang, Shou-Guo
Liang, Xiao-Wei
Gao, De-Wei
Zheng, Jun
You, Shu-Li
author_facet Yin, Qin
Wang, Shou-Guo
Liang, Xiao-Wei
Gao, De-Wei
Zheng, Jun
You, Shu-Li
author_sort Yin, Qin
collection PubMed
description An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.
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spelling pubmed-57074592017-12-07 Organocatalytic asymmetric chlorinative dearomatization of naphthols Yin, Qin Wang, Shou-Guo Liang, Xiao-Wei Gao, De-Wei Zheng, Jun You, Shu-Li Chem Sci Chemistry An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation. Royal Society of Chemistry 2015-07-01 2015-04-27 /pmc/articles/PMC5707459/ /pubmed/29218183 http://dx.doi.org/10.1039/c5sc00494b Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Yin, Qin
Wang, Shou-Guo
Liang, Xiao-Wei
Gao, De-Wei
Zheng, Jun
You, Shu-Li
Organocatalytic asymmetric chlorinative dearomatization of naphthols
title Organocatalytic asymmetric chlorinative dearomatization of naphthols
title_full Organocatalytic asymmetric chlorinative dearomatization of naphthols
title_fullStr Organocatalytic asymmetric chlorinative dearomatization of naphthols
title_full_unstemmed Organocatalytic asymmetric chlorinative dearomatization of naphthols
title_short Organocatalytic asymmetric chlorinative dearomatization of naphthols
title_sort organocatalytic asymmetric chlorinative dearomatization of naphthols
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707459/
https://www.ncbi.nlm.nih.gov/pubmed/29218183
http://dx.doi.org/10.1039/c5sc00494b
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