Cargando…
New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems
Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness. CHV-1 and FHV-1 have a pathogenesis and induce clinical disease in their hosts that is similar to HS...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707556/ https://www.ncbi.nlm.nih.gov/pubmed/29156583 http://dx.doi.org/10.3390/v9110349 |
_version_ | 1783282455796514816 |
---|---|
author | Pennington, Matthew R. Ledbetter, Eric C. Van de Walle, Gerlinde R. |
author_facet | Pennington, Matthew R. Ledbetter, Eric C. Van de Walle, Gerlinde R. |
author_sort | Pennington, Matthew R. |
collection | PubMed |
description | Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness. CHV-1 and FHV-1 have a pathogenesis and induce clinical disease in their hosts that is similar to HSV-1 ocular infections in humans, suggesting that infection of dogs and cats with CHV-1 and FHV-1, respectively, can be used as a comparative natural host model of herpesvirus-induced ocular disease. In this review, we discuss both strengths and limitations of the various available model systems to study ocular herpesvirus infection, with a focus on the use of these non-traditional virus-natural host models. Recent work has demonstrated the robustness and reproducibility of experimental ocular herpesvirus infections in dogs and cats, and, therefore, these non-traditional models can provide additional insights into the pathogenesis of ocular herpesvirus infections. |
format | Online Article Text |
id | pubmed-5707556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57075562017-12-05 New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems Pennington, Matthew R. Ledbetter, Eric C. Van de Walle, Gerlinde R. Viruses Review Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness. CHV-1 and FHV-1 have a pathogenesis and induce clinical disease in their hosts that is similar to HSV-1 ocular infections in humans, suggesting that infection of dogs and cats with CHV-1 and FHV-1, respectively, can be used as a comparative natural host model of herpesvirus-induced ocular disease. In this review, we discuss both strengths and limitations of the various available model systems to study ocular herpesvirus infection, with a focus on the use of these non-traditional virus-natural host models. Recent work has demonstrated the robustness and reproducibility of experimental ocular herpesvirus infections in dogs and cats, and, therefore, these non-traditional models can provide additional insights into the pathogenesis of ocular herpesvirus infections. MDPI 2017-11-18 /pmc/articles/PMC5707556/ /pubmed/29156583 http://dx.doi.org/10.3390/v9110349 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pennington, Matthew R. Ledbetter, Eric C. Van de Walle, Gerlinde R. New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems |
title | New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems |
title_full | New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems |
title_fullStr | New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems |
title_full_unstemmed | New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems |
title_short | New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems |
title_sort | new paradigms for the study of ocular alphaherpesvirus infections: insights into the use of non-traditional host model systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707556/ https://www.ncbi.nlm.nih.gov/pubmed/29156583 http://dx.doi.org/10.3390/v9110349 |
work_keys_str_mv | AT penningtonmatthewr newparadigmsforthestudyofocularalphaherpesvirusinfectionsinsightsintotheuseofnontraditionalhostmodelsystems AT ledbetterericc newparadigmsforthestudyofocularalphaherpesvirusinfectionsinsightsintotheuseofnontraditionalhostmodelsystems AT vandewallegerlinder newparadigmsforthestudyofocularalphaherpesvirusinfectionsinsightsintotheuseofnontraditionalhostmodelsystems |