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The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran

Back ground: Iodine deficiency is one of the important factors in increasing the recall rate in congenital hypothyroidism (CH) screening programs. The present study assessed whether the iodine status of the general population may predict the recall rate or vice versa. Methods: In the current nationa...

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Autores principales: Mehran, Ladan, Yarahmadi, Shahin, Khalili, Davood, Nazeri, Pantea, Delshad, Hossein, Abdollahi, Zahra, Azhang, Nasrin, Azizi, Fereidoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707666/
https://www.ncbi.nlm.nih.gov/pubmed/29084139
http://dx.doi.org/10.3390/nu9111194
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author Mehran, Ladan
Yarahmadi, Shahin
Khalili, Davood
Nazeri, Pantea
Delshad, Hossein
Abdollahi, Zahra
Azhang, Nasrin
Azizi, Fereidoun
author_facet Mehran, Ladan
Yarahmadi, Shahin
Khalili, Davood
Nazeri, Pantea
Delshad, Hossein
Abdollahi, Zahra
Azhang, Nasrin
Azizi, Fereidoun
author_sort Mehran, Ladan
collection PubMed
description Back ground: Iodine deficiency is one of the important factors in increasing the recall rate in congenital hypothyroidism (CH) screening programs. The present study assessed whether the iodine status of the general population may predict the recall rate or vice versa. Methods: In the current national study, among 1,382,229 live births delivered between March 2010 and March 2011, 1,288,237 neonates were screened for detecting CH by TSH (thyroid stimulating hormone) measurement via heel prick sampling. Simultaneously, a total of 11,280 school-aged children, aged 7–8 years, were selected using random multi-cluster sampling for measurement of urinary iodine. Results: A negative correlation was found between median urinary iodine (MUI) and the recall rate (r = −0.33, p = 0.03). No correlation was found between MUIC (median urinary iodine concentration) and the incidence rate of CH. Linear regression analysis showed a 0.1% increase in the recall rate for a one unit decrease in MUIC (β = −0.11, 95% CI: −0.2, −0.1, p = 0.03). MUIC, at a cut-off point of 144.7 µg/L, was predictive for a recall rate < 3% (p = 0.05). Conclusion: Frequencies of TSH ≥ 5 mU/L may be a more sensitive indicator for iodine status during pregnancy rather than in the general population. As higher recall rates reflect inadequate iodine nutrition, sufficient iodine supplementation is needed to reduce the recall rate in such communities.
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spelling pubmed-57076662017-12-05 The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran Mehran, Ladan Yarahmadi, Shahin Khalili, Davood Nazeri, Pantea Delshad, Hossein Abdollahi, Zahra Azhang, Nasrin Azizi, Fereidoun Nutrients Article Back ground: Iodine deficiency is one of the important factors in increasing the recall rate in congenital hypothyroidism (CH) screening programs. The present study assessed whether the iodine status of the general population may predict the recall rate or vice versa. Methods: In the current national study, among 1,382,229 live births delivered between March 2010 and March 2011, 1,288,237 neonates were screened for detecting CH by TSH (thyroid stimulating hormone) measurement via heel prick sampling. Simultaneously, a total of 11,280 school-aged children, aged 7–8 years, were selected using random multi-cluster sampling for measurement of urinary iodine. Results: A negative correlation was found between median urinary iodine (MUI) and the recall rate (r = −0.33, p = 0.03). No correlation was found between MUIC (median urinary iodine concentration) and the incidence rate of CH. Linear regression analysis showed a 0.1% increase in the recall rate for a one unit decrease in MUIC (β = −0.11, 95% CI: −0.2, −0.1, p = 0.03). MUIC, at a cut-off point of 144.7 µg/L, was predictive for a recall rate < 3% (p = 0.05). Conclusion: Frequencies of TSH ≥ 5 mU/L may be a more sensitive indicator for iodine status during pregnancy rather than in the general population. As higher recall rates reflect inadequate iodine nutrition, sufficient iodine supplementation is needed to reduce the recall rate in such communities. MDPI 2017-10-30 /pmc/articles/PMC5707666/ /pubmed/29084139 http://dx.doi.org/10.3390/nu9111194 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mehran, Ladan
Yarahmadi, Shahin
Khalili, Davood
Nazeri, Pantea
Delshad, Hossein
Abdollahi, Zahra
Azhang, Nasrin
Azizi, Fereidoun
The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran
title The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran
title_full The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran
title_fullStr The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran
title_full_unstemmed The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran
title_short The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran
title_sort impact of iodine status on the recall rate of the screening program for congenital hypothyroidism: findings from two national studies in iran
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707666/
https://www.ncbi.nlm.nih.gov/pubmed/29084139
http://dx.doi.org/10.3390/nu9111194
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