Epigenetic Regulatory Mechanisms Induced by Resveratrol

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in al...

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Detalles Bibliográficos
Autores principales: Fernandes, Guilherme Felipe Santos, Silva, Gabriel Dalio Bernardes, Pavan, Aline Renata, Chiba, Diego Eidy, Chin, Chung Man, Dos Santos, Jean Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707673/
https://www.ncbi.nlm.nih.gov/pubmed/29104258
http://dx.doi.org/10.3390/nu9111201
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author Fernandes, Guilherme Felipe Santos
Silva, Gabriel Dalio Bernardes
Pavan, Aline Renata
Chiba, Diego Eidy
Chin, Chung Man
Dos Santos, Jean Leandro
author_facet Fernandes, Guilherme Felipe Santos
Silva, Gabriel Dalio Bernardes
Pavan, Aline Renata
Chiba, Diego Eidy
Chin, Chung Man
Dos Santos, Jean Leandro
author_sort Fernandes, Guilherme Felipe Santos
collection PubMed
description Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
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spelling pubmed-57076732017-12-05 Epigenetic Regulatory Mechanisms Induced by Resveratrol Fernandes, Guilherme Felipe Santos Silva, Gabriel Dalio Bernardes Pavan, Aline Renata Chiba, Diego Eidy Chin, Chung Man Dos Santos, Jean Leandro Nutrients Review Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1). MDPI 2017-11-01 /pmc/articles/PMC5707673/ /pubmed/29104258 http://dx.doi.org/10.3390/nu9111201 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fernandes, Guilherme Felipe Santos
Silva, Gabriel Dalio Bernardes
Pavan, Aline Renata
Chiba, Diego Eidy
Chin, Chung Man
Dos Santos, Jean Leandro
Epigenetic Regulatory Mechanisms Induced by Resveratrol
title Epigenetic Regulatory Mechanisms Induced by Resveratrol
title_full Epigenetic Regulatory Mechanisms Induced by Resveratrol
title_fullStr Epigenetic Regulatory Mechanisms Induced by Resveratrol
title_full_unstemmed Epigenetic Regulatory Mechanisms Induced by Resveratrol
title_short Epigenetic Regulatory Mechanisms Induced by Resveratrol
title_sort epigenetic regulatory mechanisms induced by resveratrol
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707673/
https://www.ncbi.nlm.nih.gov/pubmed/29104258
http://dx.doi.org/10.3390/nu9111201
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